100% Original Factory Sglt2 Inhibitor Canagliflozin - Dabigatran Etexilate Mesylate – CPF
100% Original Factory Sglt2 Inhibitor Canagliflozin - Dabigatran Etexilate Mesylate – CPF Detail:
Description
Dabigatran etexilate mesylate (BIBR 1048MS) is an orally active prodrug of Dabigatran. Dabigatran etexilate mesylate has anticoagulant effects and is used for the prophylaxis of venousthromboembolism and stroke due to atrial fibrillation.
Background
Description: IC50 Value: 4.5nM (Ki); 10nM(Thrombin-induced platelet aggregation) [1] Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI) undergoing advanced clinical development as its orally active prodrug,dabigatran etexilate. in vitro: Dabigatran selectively and reversibly inhibited human thrombin(Ki: 4.5 nM) as well as thrombin-induced platelet aggregation (IC(50): 10 nM), while showing no inhibitory effect on other platelet-stimulating agents.Thrombin generation in platelet-poor plasma (PPP), measured as the endogenous thrombin potential (ETP) was inhibited concentration-dependently (IC(50): 0.56 microM). Dabigatran demonstrated concentration-dependent anticoagulant effects in various species in vitro, doubling the activated partial thromboplastin time (aPTT), prothrombin time (PT) and ecarin clotting time (ECT) in human PPP at concentrations of 0.23, 0.83 and 0.18 microM, respectively [1]. in vivo: Dabigatran prolonged the aPTT dose-dependently after intravenous administration in rats (0.3, 1 and 3 mg/kg) and rhesus monkeys (0.15, 0.3 and 0.6 mg/kg). Dose- and time-dependent anticoagulant effects were observed with dabigatran etexilate administered orally to conscious rats (10, 20 and 50 mg/kg) or rhesus monkeys (1, 2.5 or 5 mg/kg), with maximum effects observed between 30 and 120 min after administration, respectively [1]. Patients treated with dabigatran etexilate experienced fewer ischaemic strokes (3.74 dabigatran etexilate vs 3.97 warfarin) and fewer combined intracranial haemorrhages and haemorrhagic strokes (0.43 dabigatran etexilate vs 0.99 warfarin) per 100 patient-years [2]. Clinical trial: An Evaluation of the Pharmacokinetics and Pharmacodynamics of Oral Dabigatran Etexilate in Hemodialysis Patients . Phase1
Storage
Powder |
-20°C |
3 years |
4°C |
2 years | |
In solvent |
-80°C |
6 months |
-20°C |
1 month |
Clinical Trial
NCT Number | Sponsor | Condition | Start Date |
Phase |
NCT02170792 | Boehringer Ingelheim | Healthy | February 2001 |
Phase 1 |
NCT02170974 | Boehringer Ingelheim | Healthy | July 2004 |
Phase 1 |
NCT02170831 | Boehringer Ingelheim | Healthy | May 1999 |
Phase 1 |
NCT02170805 | Boehringer Ingelheim | Healthy | April 2001 |
Phase 1 |
NCT02170610 | Boehringer Ingelheim | Healthy | March 2002 |
Phase 1 |
NCT02170909 | Boehringer Ingelheim | Healthy | December 2004 |
Phase 1 |
NCT02171000 | Boehringer Ingelheim | Healthy | April 2005 |
Phase 1 |
NCT02170844 | Boehringer Ingelheim | Healthy | June 2004 |
Phase 1 |
NCT02170584 | Boehringer Ingelheim | Healthy | January 2001 |
Phase 1 |
NCT02170935 | Boehringer Ingelheim | Venous Thromboembolism | April 2002 |
Phase 2 |
NCT02170636 | Boehringer Ingelheim | Healthy | January 2002 |
Phase 1 |
NCT02170766 | Boehringer Ingelheim | Healthy | October 2000 |
Phase 1 |
NCT02171442 | Boehringer Ingelheim | Healthy | April 2002 |
Phase 1 |
NCT02170896 | Boehringer Ingelheim | Healthy | October 2001 |
Phase 1 |
NCT02173730 | Boehringer Ingelheim | Healthy | November 2002 |
Phase 1 |
NCT02170623 | Boehringer Ingelheim | Healthy | February 2002 |
Phase 1 |
NCT02170116 | Boehringer Ingelheim | Healthy | November 1998 |
Phase 1 |
NCT02170597 | Boehringer Ingelheim | Healthy | August 2003 |
Phase 1 |
NCT01225822 | Boehringer Ingelheim | Venous Thromboembolism | November 2002 |
Phase 2 |
NCT02170701 | Boehringer Ingelheim | Venous Thromboembolism | October 2000 |
Phase 2 |
NCT02170740 | Boehringer Ingelheim | Healthy | November 1999 |
Phase 1 |
NCT02170922 | Boehringer Ingelheim | Healthy | July 1999 |
Phase 1 |
Chemical structure
Proposal 18 Quality Consistency Evaluation projects which have approved 4, and 6 projects are under approving.
Advanced international quality management system has laid solid foundation for sales.
Quality supervision runs through the whole life cycle of the product to ensure the quality and therapeutic effect.
Professional Regulatory Affairs team supports the quality demands during the application and registration.
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International cooperation
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We are going to dedicate ourselves to providing our esteemed buyers together with the most enthusiastically thoughtful products and services for 100% Original Factory Sglt2 Inhibitor Canagliflozin - Dabigatran Etexilate Mesylate – CPF , The product will supply to all over the world, such as: Tunisia, kazan, Mali, Based on our guiding principle of quality is the key to development, we continually strive to exceed our customers' expectations. As such, we sincerely invite all interested companies to contact us for future cooperation, We welcome old and new customers to hold hands together for exploring and developing; For more information, be sure to feel free to contact us. Thanks. Advanced equipment, strict quality control, customer-orientation service, initiative summary and improvement of defects and extensive industry experience enable us to guarantee more customer satisfaction and reputation which, in return, brings us more orders and benefits. If you are interested in any of our merchandise, make sure you feel free to contact us. Inquiry or visit to our company are warmly welcome. We sincerely hope to start a win-win and friendly partnership with you. You can see more details in our website.
By Brook from Malta - 2017.09.29 11:19
The sales manager is very patient, we communicated about three days before we decided to cooperate, finally, we are very satisfied with this cooperation!
By Leona from India - 2018.12.10 19:03