100% Original History Of Thalidomide - Sugammadex Sodium – CPF
100% Original History Of Thalidomide - Sugammadex Sodium – CPF Detail:
舒更葡糖钠 | Sugammadex Sodium | 343306-79-6 | In-House |
Description
Sugammadex sodium is a synthetic γ-cyclodextrin derivative, and acts as a new reversal agent for neuromuscular block.
Generic Name: sugammadex (soo GAM ma dex)
Brand Name: Bridion
Sugammadex reverses the effects of certain medications that are given during surgical procedures to relax your muscles.
Sugammadex is used at the end of surgery, to help restore muscle function that has been blocked during surgery by the other medicines.
Sugammadex may also be used for purposes not listed in this medication guide.
It is used to reverse the effects of some drugs.
In Vivo
Injection of sugammadex has no significant effects on blood pressure or heart rate. After injection of the high rocuronium dose, the 90% recovery of the train-of-four ratio takes 28 min (SD 7 min) after saline, 26 min (SD 9.5 min) after 1 mg/kg sugammadex, and 8 min (SD 3.6 min) after 2.5 mg/kg sugammadex[1]. Sugammadex causes a rapid and complete reversal of rocuronium-induced neuromuscular block. The recovery time to train of four ratio=0.9 after spontaneous recovery is 14.4 min (SD=3.4 min; n=14). This is reduced significantly to 3.7 min (SD=3.3 min; n=4) with sugammadex 0.5 mg/kg and to 1.9 min (SD=1.0 min; n=4) with sugammadex 1.0 mg/kg[2]. The estimated half-life of sugammadex in Rhesus monkey is 30 (SEM=4.9) min[3].
Storage
Powder |
-20°C |
3 years |
4°C |
2 years | |
In solvent |
-80°C |
6 months |
-20°C |
1 month |
Chemical structure
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Quality supervision runs through the whole life cycle of the product to ensure the quality and therapeutic effect.
Professional Regulatory Affairs team supports the quality demands during the application and registration.
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