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100% Original Rosuvastatin Calcium 20 Mg Tab - Venetoclax 1257044-40-8 – CPF

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  • 100% Original Rosuvastatin Calcium 20 Mg Tab - Venetoclax 1257044-40-8 – CPF

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100% Original Rosuvastatin Calcium 20 Mg Tab - Venetoclax 1257044-40-8 – CPF Detail:

维奈妥拉 Venetoclax 1257044-40-8 In-House
    VCL-6A 98549-88-3 In-House
    VCL-7A 1235865-75-4 In-House
    VCLM2 1228780-72-0 In-House
    VCLM2-2HCl 1628047-87-9 In-House
    VCLM3 1228779-96-1 In-House

Generic Name: venetoclax (ven ET oh klax)
Brand Name: Venclexta, Venclexta Starting Pack

Venetoclax is used to treat chronic lymphocytic leukemia or small lymphocytic leukemia in adults. Venetoclax is used alone or in combination with other cancer medicines to treat these conditions.

Venetoclax is used in combination with azacitidine, decitabine, or cytarabine to treat acute myeloid leukemia. This combination is for use in adults who are 75 years or older, or who cannot use standard chemotherapy due to other medical conditions.

Venetoclax is sometimes given after other treatments have failed.

Venetoclax may also be used for purposes not listed in this medication guide.

Description

Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy.

In Vitro

Venetoclax (ABT-199) potently kills FL5.12-BCL-2 cells (EC50=4 nM), Venetoclax (ABT-199) shows much weaker activity against FL5.12-BCL-XL cells (EC50=261 nM). ABT-199 also shows selectivity in cellular mammalian two-hybrid assays, where it disrupts BCL-2-BIM complexes (EC50=3 nM) but is much less effective against BCL-XL-BCL-XS (EC50=2.2 μM) or MCL-1-NOXA complexes.

After a single oral dose of 12.5 mg per kg body weight in xenografts derived from RS4;11 cells (ALL), Venetoclax (ABT-199) causes a maximal tumor growth inhibition (TGImax) of 47% (P<0.001) and tumor growth delay (TGD) of 26% (P<0.05)[1].

Treatment of established xenografted (a mouse xenograft model of the T-ALL cell line LOUCY) tumors with Venetoclax (ABT-199) 100 mg/kg for 4 days results in a significant reduction of leukemic burden.

Storage

Powder

-20°C

 3 years

4°C

 2 years
In solvent

-80°C

 6 months

-20°C

 1 month

Chemical structure

Venetoclax 1257044-40-8

2018 GMP-2
原料药GMP证书201811（captopril ,thalidomide etc）
GMP-of-PMDA-in-Chanyoo-平成28年08月03日　Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

OUR STRENGTH

Quality management1

Proposal 18 Quality Consistency Evaluation projects which have approved 4, and 6 projects are under approving.

Quality management2

Advanced international quality management system has laid solid foundation for sales.

Quality management3

Quality supervision runs through the whole life cycle of the product to ensure the quality and therapeutic effect.

Quality management4

Professional Regulatory Affairs team supports the quality demands during the application and registration.


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International cooperation
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Domestic cooperation

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100% Original Rosuvastatin Calcium 20 Mg Tab - Venetoclax 1257044-40-8 – CPF detail pictures

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We now have several exceptional workers customers good at marketing, QC, and working with types of troublesome trouble during the creation system for 100% Original Rosuvastatin Calcium 20 Mg Tab - Venetoclax 1257044-40-8 – CPF , The product will supply to all over the world, such as: Armenia, Muscat, Melbourne, We have a dedicated and aggressive sales team, and many branches, catering to our customers. We are looking for long-term business partnerships, and ensure our suppliers that they will definitely benefit in both short and long run.
    • Managers are visionary, they have the idea of "mutual benefits, continuous improvement and innovation", we have a pleasant conversation and Cooperation.
    5 Stars By Elaine from Curacao - 2018.09.29 13:24
    Although we are a small company, we are also respected. Reliable quality, sincere service and good credit, we are honored to be able to work with you!
    5 Stars By Ann from France - 2017.09.28 18:29
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