China Cheap PriceList for Canagliflozin Metformin - Agomelatine – CPF manufacturers and suppliers

Cheap PriceList for Canagliflozin Metformin - Agomelatine – CPF

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Along with the "Client-Oriented" small business philosophy, a rigorous high-quality handle system, highly developed producing machines and a powerful R&D group, we always supply high-quality products and solutions, fantastic services and aggressive costs for Amlodipine And Hydrochlorothiazide Tablets, Thalidomide Uses, Doxycycline Hyclate For Sinus, First business, we learn each other. Further business, the trust is getting there. Our company always at your service at any time.

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Background

Agomelatine is an agonist of melatonin receptors and an antagonist of the serotonin 5-HT2C receptor with Ki values of 0.062nM and 0.268nM and IC50 value of 0.27μM, respectively for MT1, MT2 and 5-HT2C [1].

Agomelatine is a unique antidepressant and is developed for treatment of major depressive disorder (MDD). Agomelatine is selective against 5-HT2C. It shows low affinities to cloned human 5-HT2A and 5-HT1A. For melatonin receptors, agomelatine shows similar affinities to cloned human MT1 and MT2 with Ki values of 0.09nM and 0.263nM, respectively. In the in vivo studies, agomelatine causes increase of dopamine and noradrenaline levels via blocking the inhibitory input of 5-HT2C. Moreover, the administration of agomelatine counteractes the stress-induced decrease in sucrose consumption in a rat model of depression. Besides that, agomelatine exerts alleviated anxiety efficacy in a rodent model of anxiety [1].

References:
[1] Zupancic M, Guilleminault C. Agomelatine. CNS drugs, 2006, 20(12): 981-992.

Chemical structure

Agomelatine

2018 GMP-2
原料药GMP证书201811（captopril ,thalidomide etc）
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Proposal 18 Quality Consistency Evaluation projects which have approved 4, and 6 projects are under approving.

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carry on to further improve, to guarantee merchandise high-quality in line with market and buyer standard necessities. Our organization has a top quality assurance procedure have already been established for Cheap PriceList for Canagliflozin Metformin - Agomelatine – CPF , The product will supply to all over the world, such as: Florida, Switzerland, Argentina, Only for accomplishing the good-quality product to meet customer's demand, all of our products have been strictly inspected before shipment. We always think about the question on the side of the customers, because you win, we win!

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