China China Wholesale Brilinta Ticagrelor 90 Mg Suppliers - Tofacitnib Citrate – CPF manufacturers and suppliers

China Wholesale Brilinta Ticagrelor 90 Mg Suppliers - Tofacitnib Citrate – CPF

Short Description:

Product Detail

Product Tags

Feedback (2)

While using the "Client-Oriented" organization philosophy, a rigorous top quality command process, highly developed production devices and a potent R&D workforce, we normally provide high quality products, outstanding solutions and aggressive charges for Credence Trial Canagliflozin, Losartan Hydrochlorothiazide 100 Mg 25 Mg, Hydrochlorothiazide Generic, We give priority to quality and customer satisfaction and for this we follow stringent quality control measures. We have in-house testing facilities where our products are tested on every aspect at different processing stages. Owning to latest technologies, we facilitate our customers with customized production facility.

China Wholesale Brilinta Ticagrelor 90 Mg Suppliers - Tofacitnib Citrate – CPF Detail:

Background

Tofacitinib citrate, also known as CP-690550 citrate, is a potent inhibitor of janus kinase 3 (JAK3), a hematopoetic cell-restricted tyrosine kinase involved in signal transduction regulating lymphocyte survival, proliferation, differentiation, and apoptosis. The inhibition is JAK3 specific with a selectivity 1000-fold more than other non-JAK family kinases. Besides inhibiting JAKS (IC50 = 1 nM), tofacitinib citrate also inhibits janus kinase 2 (JAK2) and janus kinase 1 (JAK1) with 20- and 100-fold less in potency respectively. However, in a recent study, the binding affinities (Ki) of tofacitinib citrate towards JAK1, JAK2, and JAK3 were reported to be 1.6 nM, 21.7 nM, and 6.5 nM respectively.

Reference

Lalitha Vijayakrishnan, R. Venkataramanan and Palak Gulati. Treating inflammation with the janus kinase inhibitor CP-690,550. Trends in Pharmacological Sciences 2011: 32 (1); 25-34

Product Citation

1. Panagi I, Jennings E, et al. “Salmonella Effector SteE Converts the Mammalian Serine/Threonine Kinase GSK3 into a Tyrosine Kinase to Direct Macrophage Polarization.” Cell Host Microbe. 2020;27(1):41–53.e6. PMID:31862381
2. McInnes IB, Byers NL, et al. “Comparison of baricitinib, upadacitinib, and tofacitinib mediated regulation of cytokine signaling in human leukocyte subpopulations.” Arthritis Res Ther. 2019 Aug 2;21(1):183. PMID:31375130
3. Liu S, Verma M, et al. “Steroid resistance of airway type 2 innate lymphoid cells from patients with severe asthma: The role of thymic stromal lymphopoietin.”J Allergy Clin Immunol. 2018 Jan;141(1):257-268.e6. PMID:28433687
4. Zheng, Lufeng, et al. “The 3′ UTR of the pseudogene CYP4Z2P promotes tumor angiogenesis in breast cancer by acting as a ceRNA for CYP4Z1.” Breast cancer research and treatment (2015): 1-14. PMID:25701119

Description

Tofacitinib citrate is an orally available JAK1/2/3 inhibitor with IC50s of 1, 20, and 112 nM, respectively. Tofacitinib citrate has antibacterial, antifungal and antiviral activities.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Chemical structure

Tofacitnib Citrate

Related Biological Data

Tofacitnib Citrate2

Related Biological Data

Tofacitnib Citrate3

Related Biological Data

Tofacitnib Citrate4

Related Biological Data

Tofacitnib Citrate5

Related Biological Data

Tofacitnib Citrate6

2018 GMP-2
原料药GMP证书201811（captopril ,thalidomide etc）
GMP-of-PMDA-in-Chanyoo-平成28年08月03日　Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

OUR STRENGTH

Quality management1

Proposal 18 Quality Consistency Evaluation projects which have approved 4, and 6 projects are under approving.

Quality management2

Advanced international quality management system has laid solid foundation for sales.

Quality management3

Quality supervision runs through the whole life cycle of the product to ensure the quality and therapeutic effect.

Quality management4

Professional Regulatory Affairs team supports the quality demands during the application and registration.

VIEW MORE

VIEW MORE

International cooperation

Domestic cooperation

Product detail pictures:

Related Product Guide:

We are ready to share our knowledge of marketing worldwide and recommend you suitable products at most aggressive costs. So Profi Tools offer you finest benefit of money and we are ready to produce alongside one another with China Wholesale Brilinta Ticagrelor 90 Mg Suppliers - Tofacitnib Citrate – CPF , The product will supply to all over the world, such as: New Zealand, Swiss, Jeddah, With the development and enlargement of mass clients abroad, now we have set up cooperative relationships with many major brands. We have our own factory and also have many reliable and well-cooperated factories in the field. Adhering to the "quality first, customer first, We are provideing high-quality, low-cost products and first-class service to customers. We sincerely hope to establish business relationship with customers from all over the world on the basis of quality, mutually benefit. We welcome OEM projects and designs.

Daclatasvir Plus Sofosbuvir