China Wholesale Rosuvastatin Calcium 10 Suppliers - Canagliflozin – CPF
China Wholesale Rosuvastatin Calcium 10 Suppliers - Canagliflozin – CPF Detail:
Background
Canagliflozin is a novel, potent, and highly selective sodium glucose co-transporter (SGLT) 2 inhibitor [1]. It has been proved that Canagliflozin can increase urine glucose excretion by reducing the renal glucose threshold and by decreasing the filtered glucose re-absorption [2].
Canagliflozin has been shown to inhibit the Na+-mediated 14C-AMG intakes in CHO-hSGLT2, CHO-rat SGLT2 and CHO-mouse SGLT2 with IC50 values of 4.4, 3.7 and 2.0 nM, respectively [1].
Canagliflozin has been reported to reduce the blood glucose (BG) levels dose-dependently in both db/db Mice and Zucker diabetic fatty (ZDF) Rats. Additionally, canagliflozin has proved to decrease the respiratory exchange ratio, and body weight in DIO mice and ZDF rats [1].
Canagliflozin can be taken orally [1].
References:
[1] Liang Y1, Arakawa K, Ueta K, Matsushita Y, Kuriyama C Martin T, Du F, Liu Y, Xu J, Conway B, Conway J, Polidori D, Ways K, Demarest K. Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models. PLoS One. 2012;7(2):e30555
[2] Sarnoski-Brocavich S, Hilas O. Canagliflozin (Invokana), a Novel Oral Agent For Type-2 Diabetes. P T. 2013 Nov;38(11):656-66
Product Citation
Bahia Abbas Moussa, Marianne Alphonse Mahrouse, et al. “Different resolution techniques for management of overlapped spectra: Application for the determination of novel co-formulated hypoglycemic drugs in their combined pharmaceutical dosage form.” Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Available online 20 June 2018.
Chemical structure
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We are convinced that with joint efforts, the business between us will bring us mutual benefits. We can assure you product quality and competitive price for China Wholesale Rosuvastatin Calcium 10 Suppliers - Canagliflozin – CPF , The product will supply to all over the world, such as: UK, Algeria, Mexico, By continuous innovation, we will present you with more valuable items and services, and also make a contribution for the development of the automobile industry at home and abroad. Both domestic and foreign merchants are strongly welcomed to join us to grow together.
By Nicola from Peru - 2018.02.12 14:52
The accounts manager made a detailed introduction about the product, so that we have a comprehensive understanding of the product, and ultimately we decided to cooperate.
By Janet from Spain - 2017.06.29 18:55