China Wholesale Rosuvastatin Calcium 5 Mg Tab Quotes - Agomelatine – CPF
China Wholesale Rosuvastatin Calcium 5 Mg Tab Quotes - Agomelatine – CPF Detail:
Background
Agomelatine is an agonist of melatonin receptors and an antagonist of the serotonin 5-HT2C receptor with Ki values of 0.062nM and 0.268nM and IC50 value of 0.27μM, respectively for MT1, MT2 and 5-HT2C [1].
Agomelatine is a unique antidepressant and is developed for treatment of major depressive disorder (MDD). Agomelatine is selective against 5-HT2C. It shows low affinities to cloned human 5-HT2A and 5-HT1A. For melatonin receptors, agomelatine shows similar affinities to cloned human MT1 and MT2 with Ki values of 0.09nM and 0.263nM, respectively. In the in vivo studies, agomelatine causes increase of dopamine and noradrenaline levels via blocking the inhibitory input of 5-HT2C. Moreover, the administration of agomelatine counteractes the stress-induced decrease in sucrose consumption in a rat model of depression. Besides that, agomelatine exerts alleviated anxiety efficacy in a rodent model of anxiety [1].
References:
[1] Zupancic M, Guilleminault C. Agomelatine. CNS drugs, 2006, 20(12): 981-992.
Chemical structure
Proposal 18 Quality Consistency Evaluation projects which have approved 4, and 6 projects are under approving.
Advanced international quality management system has laid solid foundation for sales.
Quality supervision runs through the whole life cycle of the product to ensure the quality and therapeutic effect.
Professional Regulatory Affairs team supports the quality demands during the application and registration.
VIEW MORE
VIEW MORE
International cooperation
Domestic cooperation
Product detail pictures:
Related Product Guide:
We emphasize enhancement and introduce new solutions into the market just about every year for China Wholesale Rosuvastatin Calcium 5 Mg Tab Quotes - Agomelatine – CPF , The product will supply to all over the world, such as: Somalia, Venezuela, Mexico, Our products have been obtained more and more recognition from foreign clients, and established long term and cooperative relationship with them. We`ll provide the best service for every customer and sincerely welcome friends to work with us and establish the mutual benefit together.
By Christine from Paraguay - 2018.02.12 14:52
As a veteran of this industry, we can say that the company can be a leader in the industry, select them is right.
By Kimberley from Russia - 2017.08.15 12:36