China Wholesale Rosuvastatin Calcium Tablet Uses Manufacturers - Tofacitnib Citrate – CPF
China Wholesale Rosuvastatin Calcium Tablet Uses Manufacturers - Tofacitnib Citrate – CPF Detail:
Background
Tofacitinib citrate, also known as CP-690550 citrate, is a potent inhibitor of janus kinase 3 (JAK3), a hematopoetic cell-restricted tyrosine kinase involved in signal transduction regulating lymphocyte survival, proliferation, differentiation, and apoptosis. The inhibition is JAK3 specific with a selectivity 1000-fold more than other non-JAK family kinases. Besides inhibiting JAKS (IC50 = 1 nM), tofacitinib citrate also inhibits janus kinase 2 (JAK2) and janus kinase 1 (JAK1) with 20- and 100-fold less in potency respectively. However, in a recent study, the binding affinities (Ki) of tofacitinib citrate towards JAK1, JAK2, and JAK3 were reported to be 1.6 nM, 21.7 nM, and 6.5 nM respectively.
Reference
Lalitha Vijayakrishnan, R. Venkataramanan and Palak Gulati. Treating inflammation with the janus kinase inhibitor CP-690,550. Trends in Pharmacological Sciences 2011: 32 (1); 25-34
Product Citation
- 1. Panagi I, Jennings E, et al. “Salmonella Effector SteE Converts the Mammalian Serine/Threonine Kinase GSK3 into a Tyrosine Kinase to Direct Macrophage Polarization.” Cell Host Microbe. 2020;27(1):41–53.e6. PMID:31862381
- 2. McInnes IB, Byers NL, et al. “Comparison of baricitinib, upadacitinib, and tofacitinib mediated regulation of cytokine signaling in human leukocyte subpopulations.” Arthritis Res Ther. 2019 Aug 2;21(1):183. PMID:31375130
- 3. Liu S, Verma M, et al. “Steroid resistance of airway type 2 innate lymphoid cells from patients with severe asthma: The role of thymic stromal lymphopoietin.”J Allergy Clin Immunol. 2018 Jan;141(1):257-268.e6. PMID:28433687
- 4. Zheng, Lufeng, et al. “The 3′ UTR of the pseudogene CYP4Z2P promotes tumor angiogenesis in breast cancer by acting as a ceRNA for CYP4Z1.” Breast cancer research and treatment (2015): 1-14. PMID:25701119
Description
Tofacitinib citrate is an orally available JAK1/2/3 inhibitor with IC50s of 1, 20, and 112 nM, respectively. Tofacitinib citrate has antibacterial, antifungal and antiviral activities.
Storage
4°C, protect from light
*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Chemical structure
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Proposal 18 Quality Consistency Evaluation projects which have approved 4, and 6 projects are under approving.
Advanced international quality management system has laid solid foundation for sales.
Quality supervision runs through the whole life cycle of the product to ensure the quality and therapeutic effect.
Professional Regulatory Affairs team supports the quality demands during the application and registration.
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We have now a skilled, performance group to offer excellent support for our consumer. We usually follow the tenet of customer-oriented, details-focused for China Wholesale Rosuvastatin Calcium Tablet Uses Manufacturers - Tofacitnib Citrate – CPF , The product will supply to all over the world, such as: Angola, Swiss, kazan, Now we have a excellent team supplying specialist service, prompt reply, timely delivery, excellent quality and best price to our customers. Satisfaction and good credit to every customer is our priority. We have been sincerely looking forward to cooperate with customers all over the world. We believe we can satisfy with you. We also warmly welcome customers to visit our company and purchase our solutions.
By Julie from Netherlands - 2017.04.28 15:45
Company director has very rich management experience and strict attitude, sales staff are warm and cheerful, technical staff are professional and responsible,so we have no worry about product,a nice manufacturer.
By Claire from Mombasa - 2017.09.26 12:12