China Wholesale Ticagrelor 180 Mg Manufacturers - Agomelatine – CPF
China Wholesale Ticagrelor 180 Mg Manufacturers - Agomelatine – CPF Detail:
Background
Agomelatine is an agonist of melatonin receptors and an antagonist of the serotonin 5-HT2C receptor with Ki values of 0.062nM and 0.268nM and IC50 value of 0.27μM, respectively for MT1, MT2 and 5-HT2C [1].
Agomelatine is a unique antidepressant and is developed for treatment of major depressive disorder (MDD). Agomelatine is selective against 5-HT2C. It shows low affinities to cloned human 5-HT2A and 5-HT1A. For melatonin receptors, agomelatine shows similar affinities to cloned human MT1 and MT2 with Ki values of 0.09nM and 0.263nM, respectively. In the in vivo studies, agomelatine causes increase of dopamine and noradrenaline levels via blocking the inhibitory input of 5-HT2C. Moreover, the administration of agomelatine counteractes the stress-induced decrease in sucrose consumption in a rat model of depression. Besides that, agomelatine exerts alleviated anxiety efficacy in a rodent model of anxiety [1].
References:
[1] Zupancic M, Guilleminault C. Agomelatine. CNS drugs, 2006, 20(12): 981-992.
Chemical structure
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To be able to ideal satisfy client's requirements, all of our operations are strictly performed in line with our motto "High High-quality, Competitive Price tag, Fast Service" for China Wholesale Ticagrelor 180 Mg Manufacturers - Agomelatine – CPF , The product will supply to all over the world, such as: Slovenia, Norway, Boston, In the increasingly competitive market, With sincere service high quality products and well-deserved reputation, we always offer customers support on products and techniques to achieve long-term cooperation. Living by quality, development by credit is our eternal pursuit, We firmly believe that after your visit we will become long-term partners.
By Meroy from Czech - 2018.12.22 12:52
Wide range, good quality, reasonable prices and good service, advanced equipment, excellent talents and continuously strengthened technology forces,a nice business partner.
By Tony from Azerbaijan - 2017.02.18 15:54