China Wholesale Ticagrelor 90 Manufacturers - Bictegravir 1611493-60-7 – CPF

Short Description:


Product Detail

Product Tags

Related Video

Feedback (2)

The very rich projects management experiences and one to one service model make the high importance of business communication and our easy understanding of your expectations for Irbesartan And Hydrochlorothiazide Tablets, Fenofibrate Rosuvastatin Calcium, Rosuvastatin Calcium Tablets Ip 5mg, Our team members are aim to provides products with high performance cost ratio to our customers, and the goal for all of us is to satisfy our consumers from all over the world.
China Wholesale Ticagrelor 90 Manufacturers - Bictegravir 1611493-60-7 – CPF Detail:

Description

Bictegravir is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.

In Vitro

Bictegravir (BIC) inhibits the strand transfer activity with an IC50 of 7.5± 0.3 nM. Relative to its inhibition of strand transfer activity, Bictegravir is a much weaker inhibitor of 3′-processing activity of HIV-1 IN, with an IC50 of 241±51 nM. Bictegravir enhances the accumulation of 2-LTR circles ~5-fold relative to the mock-treated control and reduces the amount of authentic integration products in infected cells by 100-fold. Bictegravir potently inhibits HIV-1 replication in both MT-2 and MT-4 cells with EC50s of 1.5 and 2.4 nM, respectively. Bictegravir exhibits potent antiviral effects in both primary CD4+ T lymphocytes and monocyte-derived macrophages, with EC50s of 1.5±0.3 nM and 6.6±4.1 nM, respectively, which are comparable to values obtained in T-cell lines[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NCT Number Sponsor Condition Start Date

Phase

NCT03998176 University of Nebraska|Gilead Sciences HIV-1-infection October 9, 2019

Phase 4

NCT03789968 Thomas Jefferson University|University of Maryland, College Park|Indiana University Health|The Brooklyn Hospital Center|University of Illinois at Chicago|Nova Southeastern University|University of California, San Francisco HIV+AIDS September 1, 2019
NCT04249037 University of Colorado, Denver|Gilead Sciences HIV+AIDS March 1, 2020

Not Applicable

NCT04132674 Vancouver Infectious Diseases Centre Human Immunodeficiency Virus I Infection|Drug Use November 26, 2018

Phase 4

NCT04054089 Cristina Mussini|University of Modena and Reggio Emilia HIV Infections September 2019

Phase 4

NCT04155554 Azienda Ospedaliera Universitaria Senese|Catholic University of the Sacred Heart|Ospedale Policlinico San Martino|Azienda Ospedaliera San Paolo|Ospedale Amedeo di Savoia HIV-1-infection January 29, 2020

Phase 3

NCT02275065 Gilead Sciences HIV-1 Infection October 2014

Phase 1

NCT03711253 University of Southern California Acute HIV Infection October 14, 2019

Phase 4

NCT02400307 Gilead Sciences HIV April 17, 2015

Phase 1

NCT03499483 Fenway Community Health HIV Prevention January 24, 2019

Phase 4

NCT03502005 Midland Research Group, Inc.|Gilead Sciences Human Immunodeficiency Virus March 1, 2018

Phase 4

Chemical structure

Bictegravir-1611493-60-7

2018 GMP-2
原料药GMP证书201811(captopril ,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

OUR STRENGTH

Quality management1

Proposal 18 Quality Consistency Evaluation projects which have approved 4, and 6 projects are under approving.

Quality management2

Advanced international quality management system has laid solid foundation for sales.

Quality management3

Quality supervision runs through the whole life cycle of the product to ensure the quality and therapeutic effect. 

Quality management4

Professional Regulatory Affairs team supports the quality demands during the application and registration.


VIEW MORE


VIEW MORE

International cooperation
International cooperation
Domestic cooperation
Domestic cooperation


Product detail pictures:

China Wholesale Ticagrelor 90 Manufacturers - Bictegravir 1611493-60-7  – CPF detail pictures


Related Product Guide:

"Sincerity, Innovation, Rigorousness, and Efficiency" could be the persistent conception of our organization for your long-term to establish alongside one another with shoppers for mutual reciprocity and mutual benefit for China Wholesale Ticagrelor 90 Manufacturers - Bictegravir 1611493-60-7 – CPF , The product will supply to all over the world, such as: Canada, Jordan, Latvia, Be sure to feel cost-free to send us your specs and we are going to respond for you asap. We have got a experienced engineering team to serve for the every single comprehensive needs. Free samples may be sent for yourself personally to know far more facts. So that you can meet your desires, please actually feel cost-free to contact us. You could send us emails and call us straight. Additionally, we welcome visits to our factory from all over the world for much better recognizing of our corporation. nd merchandise. In our trade with merchants of several countries, we often adhere to the principle of equality and mutual advantage. It is our hope to market, by joint efforts, both trade and friendship to our mutual benefit. We look forward to getting your inquiries.
  • The goods we received and the sample sales staff display to us have the same quality, it is really a creditable manufacturer.
    5 Stars By Kitty from Bolivia - 2018.09.29 13:24
    A nice supplier in this industry, after a detail and careful discussion, we reached a consensus agreement. Hope that we cooperate smoothly.
    5 Stars By Charlotte from Slovakia - 2017.06.16 18:23
    Write your message here and send it to us