China Doxycycline Hyclate manufacturers and suppliers

Doxycycline Hyclate

Short Description:

API’s Name	Indication	Specification	US DMF	EU DMF	CEP
Doxycycline Hyclate	Antibiotics	USP/EP	13771	√

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Background

Doxycycline hyclate is an antibiotic [1].

Doxycycline hyclate is a derivative of tetracycline and possesses the activities of anti-inflammatory and antimicrobial. Doxycycline inhibits dengue virus replication in vitro with a temperature-dependent manner. The IC50 value is 52.3μM at 37°C and 26.7μM at 40°C. It inhibits the dengue virus via inhibiting the NS2B-NS3 serine protease of the virus. 60μM doxycycline reduces the CPE of the DNEV2-infected cells [1].

Doxycycline is found to be an inhibitor of MMP. Doxycycline treatment reduces MMP-8 and -9 levels and inhibits expression of tissue MMP-2 and MMP-9. Moreover, treatment with doxycycline significantly reduces the incidence of intracranial aneurysms. Doxycycline has also been reported to be an anti-inflammatory agent based on its inhibition of matrix metalloproteinases. In addition, doxycycline has potent antimalarial activity with IC50 value of 320nM at 96h in vitro [2, 3].

References:
[1] Rothan HA, Mohamed Z, Paydar M, Rahman NA, Yusof R. Inhibitory effect of doxycycline against dengue virus replication in vitro. Arch Virol. 2014 Apr;159(4):711-8.
[2] Maradni A, Khoshnevisan A, Mousavi SH, Emamirazavi SH, Noruzijavidan A. Role of matrix metalloproteinases (MMPs) and MMP inhibitors on intracranial aneurysms: a review article. Med J Islam Repub Iran. 2013 Nov;27(4):249-254.
[3] Draper MP, Bhatia B, Assefa H, Honeyman L, Garrity-Ryan LK, Verma AK, Gut J, Larson K, Donatelli J, Macone A, Klausner K, Leahy RG, Odinecs A, Ohemeng K, Rosenthal PJ, Nelson ML. In vitro and in vivo antimalarial efficacies of optimized tetracyclines. Antimicrob Agents Chemother. 2013 Jul;57(7):3131-6.

Description

Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate), an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor[1].

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT00246324	Louisiana State University Health Sciences Center Shreveport\|Biogen	Multiple Sclerosis	December 2003	Phase 4
NCT00910715	University Medical Centre Ljubljana	Erythema Chronicum Migrans	June 2009	Not Applicable
NCT00243893	University of California, San Francisco\|National Institute of Neurological Disorders and Stroke (NINDS)	Aneurysms\|Arteriovenous Malformations	July 2004	Phase 1
NCT00126399	CollaGenex Pharmaceuticals	Rosacea	June 2004	Phase 3
NCT01318356	Radboud University\|ZonMw: The Netherlands Organisation for Health Research and Development	Q Fever\|Fatigue Syndrome, Chronic\|Coxiella Infection	April 2011	Phase 4
NCT00177333	University of Pittsburgh	Abortion, Induced\|Vomiting	September 2005	Phase 4
NCT00007735	US Department of Veterans Affairs\|Pfizer\|United States Department of Defense\|VA Office of Research and Development	Persian Gulf Syndrome\|Mycoplasma Infections	January 1999	Phase 3
NCT00351273	University of South Florida\|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)	Arthritis, Reactive\|Reiter Disease	May 2006	Phase 3
NCT00469261	Careggi Hospital	Myocardial Infarction\|Left Ventricular Remodeling	May 2007	Phase 2
NCT00547170	University of Pittsburgh\|Tu Du Hospital	Endometritis	January 2007	Phase 4
NCT01475708	University Medical Centre Ljubljana	Lyme Borreliosis	May 2011
NCT01368341	Morten Lindbaek\|Norwegian Institute of Public Health\|Sorlandet Hospital HF\|Norwegian University of Life Sciences\|University of Oslo	Erythema Migrans\|Erythema Chronicum Migrans\|Borreliosis\|Lyme Disease\|Early Lyme Disease	June 2011	Phase 4
NCT02538224	Islamic Azad University, Tehran	Chronic Periodontitis	July 2013	Phase 2\|Phase 3
NCT00066027	University of Nebraska\|National Institute of Dental and Craniofacial Research (NIDCR)	Periodontitis	June 2002	Phase 3
NCT00376493	Hospital de Clinicas de Porto Alegre	Septic Abortion	May 2006	Phase 4
NCT03448731	Fundacion CRIS de Investigación para Vencer el Cáncer\|Amgen\|Apices Soluciones S.L.	Skin Toxicity	May 10, 2018	Phase 2
NCT00989742	University of Nottingham	Lymphangioleiomyomatosis\|Tuberous Sclerosis	July 2009	Phase 4
NCT01438515	Horizon Health Network	Methicillin-resistant Staphylococcus Aureus	August 2008	Not Applicable
NCT02929121	The Task Force for Global Health\|United States Agency for International Development (USAID)	Lymphedema\|Lymphatic Filariasis\|Filariasis	January 15, 2019	Phase 3
NCT00952861	Odense University Hospital\|Kolding Sygehus\|Svendborg Hospital\|Fredericia Hospital\|Naestved Hospital\|Hillerod Hospital, Denmark\|Region Syddanmark\|Danmarks Lungeforening\|Danish National Research Foundation	Pulmonary Disease, Chronic Obstructive	October 2009	Phase 4
NCT00138801	Sorlandet Hospital HF	Lyme Neuroborreliosis	March 2004	Phase 3
NCT00942006	University Medical Centre Ljubljana	Suspected Early Lyme Neuroborreliosis	July 2009	Not Applicable
NCT02713607	University of California, Davis	Acne Vulgaris	March 2016	Phase 1\|Phase 2
NCT00560703	Galderma	Blepharitis\|Meibomianitis\|Dry Eye	November 2007	Phase 2
NCT01014260	Johns Hopkins University	Cardiovascular Disease	September 2010	Phase 4
NCT00000938	National Institute of Allergy and Infectious Diseases (NIAID)	Lyme Disease		Phase 3
NCT01398072	University College, London\|Royal Free Hampstead NHS Trust\|University of Cambridge\|National Institute for Health Research, United Kingdom	Chronic Obstructive Pulmonary Disease (COPD).	December 2011	Phase 3
NCT03479502	Vanderbilt University Medical Center\|Orthopedic Research and Education Foundation	Adhesive Capsulitis\|Adhesive Capsulitis of Unspecified Shoulder\|Frozen Shoulder	January 5, 2018	Phase 4
NCT02929134	The Task Force for Global Health\|United States Agency for International Development (USAID)	Lymphedema\|Lymphatic Filariasis\|Filariasis	February 16, 2018	Phase 3
NCT00480532	Oregon Health and Science University	Contraceptives, Oral	May 2007	Not Applicable
NCT01594827	Johns Hopkins University\|Case Western Reserve University\|Cystic Fibrosis Foundation	Cystic Fibrosis	October 2012	Phase 2
NCT01744093	Weill Medical College of Cornell University\|National Heart, Lung, and Blood Institute (NHLBI)	HIV\|Chronic Obstructive Pulmonary Disease (COPD)\|Emphysema	July 17, 2014	Not Applicable
NCT03530319	National Taiwan University Hospital	Pneumonia, Mycoplasma	November 10, 2018	Not Applicable
NCT04167085	University of California, Los Angeles	Epistaxis	December 18, 2017	Phase 4
NCT01411202	Ottawa Hospital Research Institute	Malignant Pleural Effusion	June 2011	Phase 2
NCT01474590	Galderma	Acne	November 2011	Phase 3
NCT00649571	Mylan Pharmaceuticals	Healthy	July 2005	Phase 1
NCT02899000	Galderma Laboratories, L.P.	Acne Vulgaris	July 29, 2016	Phase 4
NCT00538967	Leiden University Medical Center	Aortic Aneurysm, Abdominal	May 2002	Phase 2
NCT00439400	Alacrity Biosciences, Inc.	Dry Eye	February 2007	Phase 2
NCT00917553	Thomas Gardner\|Penn State University\|Juvenile Diabetes Research Foundation\|Milton S. Hershey Medical Center	Diabetic Retinopathy	July 2009	Phase 2
NCT00495313	CollaGenex Pharmaceuticals	Rosacea	March 2007	Phase 4
NCT01855360	Brigham and Women´s Hospital	Amyloidosis; Heart (Manifestation)\|Senile Cardiac Amyloidosis	June 2013	Phase 1\|Phase 2
NCT00419848	Shahid Beheshti University of Medical Sciences	Acne	August 2006	Phase 2
NCT03532464	University Hospital, Bordeaux\|USC EA 3671 Infections humaines à mycoplasmes et à chlamydiae	Chlamydia Trachomatis Infection\|Vaginal Infection\|Anal Infection	July 1, 2018	Phase 4
NCT02756403	Medstar Health Research Institute\|Society of Family Planning	First Trimester Abortion	March 2016	Not Applicable
NCT00353158	National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)\|National Institutes of Health Clinical Center (CC)	Healthy Volunteers\|Fungal Infections\|Bacterial Infections	July 11, 2006	Phase 1
NCT01317433	Institut Cancerologie de l´Ouest	Colorectal Cancer Metastatic\|Skin Toxicity	December 2010	Phase 3
NCT01658995	Petra M. Casey\|Mayo Clinic	ESI-related Bleeding	September 13, 2012	Phase 3
NCT03968562	State University of New York - Downstate Medical Center	Hives	May 15, 2019	Phase 2
NCT02569437	Icahn School of Medicine at Mount Sinai	Polyp of Nasal Sinus	September 2014	Phase 2
NCT01198509	NYU Langone Health\|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)\|Memorial Sloan Kettering Cancer Center	Rheumatoid Arthritis\|Psoriatic Arthritis\|Periodontal Disease	January 2010	Not Applicable
NCT01163994	University Medical Centre Ljubljana	Multiple Erythema Migrans	June 2010	Not Applicable
NCT02388477	Milton S. Hershey Medical Center	Rotator Cuff Injury		Not Applicable
NCT01010295	International Extranodal Lymphoma Study Group (IELSG)	Non-Hodgkin Lymphoma	September 2006	Phase 2
NCT00775918	Ranbaxy Laboratories Limited\|Ranbaxy Inc.	Healthy	June 2005	Not Applicable
NCT04050540	University of Washington\|Kenya Medical Research Institute\|Kenya National AIDS & STI Control Programme\|University of California, San Francisco\|National Institute of Allergy and Infectious Diseases (NIAID)	HIV Infections\|HIV+AIDS\|Neisseria Gonorrheae Infection\|Chlamydia Trachomatis Infection\|Syphilis Infection	February 5, 2020	Phase 4
NCT02562651	Russian Academy of Medical Sciences	Vascular Diseases\|Cardiovascular Diseases\|Acute Myocardial Infarction	February 2014	Phase 2\|Phase 3
NCT00001101	National Institute of Allergy and Infectious Diseases (NIAID)	Lyme Disease		Phase 3
NCT00340691	National Institute of Allergy and Infectious Diseases (NIAID)\|National Institutes of Health Clinical Center (CC)	Mansonella Perstans Infection\|Mp Microfilaremia	December 6, 2004	Phase 2
NCT01112059	University of Alabama at Birmingham\|Cystic Fibrosis Foundation	Cystic Fibrosis	November 2008	Not Applicable
NCT00652704	Par Pharmaceutical, Inc.\|Anapharm	To Determine Bioequivalence Under Fed Conditions	July 1999	Phase 1
NCT01783860	Tehran University of Medical Sciences	Posterior Blepharitis	January 2013	Phase 2
NCT02564471	State University of New York - Upstate Medical University\|Walter Reed Army Institute of Research (WRAIR)\|Kansas State University	Rabies	April 2016	Phase 4
NCT04206631	Indonesia University	Acne Vulgaris	April 1, 2015	Phase 1
NCT03956446	University Medical Centre Ljubljana\|University of Ljubljana School of Medicine, Slovenia	Tick Borne Encephalitis	September 1, 2014	Not Applicable
NCT03960411	Felix Chikita Fredy, MD\|National Cardiovascular Center Harapan Kita Hospital Indonesia\|Indonesia University	ST Elevation Myocardial Infarction\|Anterior Wall Myocardial Infarction\|Heart Failure\|Remodeling, Ventricular	May 25, 2019	Phase 3
NCT00322465	National Institute of Allergy and Infectious Diseases (NIAID)	Urethritis	November 2006	Phase 2
NCT01375491	University of California, San Diego\|Ruth L. Kirschstein National Research Service Award\|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)\|National Center for Research Resources (NCRR)	Type 2 Diabetes\|Obesity	October 2009	Phase 4
NCT03478436	Medical University of Vienna\|Dr. Reddy´s Laboratories Limited	Rosacea	July 2016	Phase 1
NCT01207739	Radboud University\|Sint Maartenskliniek\|ZonMw: The Netherlands Organisation for Health Research and Development	Lyme Disease\|Borrelia Infection	September 2010	Phase 4
NCT00939562	Pfizer	Bacterial Infection	November 2008	Phase 4
NCT03608774	National Institute of Allergy and Infectious Diseases (NIAID)	Anal Chlamydia Infection	June 26, 2018	Phase 4
NCT02281643	Kwame Nkrumah University of Science and Technology\|University of Bonn\|Heinrich-Heine University, Duesseldorf	Mansonella Perstans Infection\|Buruli Ulcer\|Tuberculosis\|Co-infection	October 2014	Phase 2
NCT00066066	The Forsyth Institute\|National Institute of Dental and Craniofacial Research (NIDCR)	Periodontitis\|Periodontal Diseases	July 2003	Phase 2
NCT01798225	Medical University of South Carolina\|National Center for Research Resources (NCRR)	Periodontal Disease\|Type 2 Diabetes Mellitus	December 2007	Phase 4
NCT00612573	Warner Chilcott	Acne Vulgaris	February 2008	Phase 2
NCT01631617	National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)\|National Institutes of Health Clinical Center (CC)	Eczema\|Dermatitis\|Skin Diseases, Genetic\|Dermatitis, Atopic\|Skin Diseases	September 18, 2012	Phase 2
NCT03173053	Radboud University\|ZonMw: The Netherlands Organisation for Health Research and Development\|Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)\|Aalborg University Hospital\|Rigshospitalet, Denmark	Staphylococcus Aureus\|Motility Disorder	February 8, 2018	Not Applicable
NCT00715858	McMaster University\|The Physicians´ Services Incorporated Foundation	Alzheimer´s Disease	May 2008	Phase 3
NCT03584919	University Medical Centre Ljubljana	Erythema Chronicum Migrans	June 1, 2006	Not Applicable
NCT01469585	University of Hawaii\|Charles Drew University of Medicine and Science\|Meharry Medical College	Breakthrough Bleeding	November 2011	Not Applicable
NCT02759120	Weill Medical College of Cornell University\|Duke Clinical Research Institute\|University of Chicago\|University of Washington\|University of Pittsburgh\|National Heart, Lung, and Blood Institute (NHLBI)	Idiopathic Pulmonary Fibrosis	March 22, 2017	Phase 3
NCT02735837	Amirhossein Farahmand\|Islamic Azad University, Tehran	Diabetes Mellitus With Periodontal Disease	January 2015	Phase 2\|Phase 3
NCT03655197	University of California, Davis	Rosacea\|Ocular Rosacea\|Cutaneous Rosacea	November 2, 2017	Early Phase 1
NCT01188954	Northwell Health	Seroma	January 2010	Not Applicable
NCT00388778	Shahid Beheshti University of Medical Sciences	Acne\|Inflammation	October 2005	Phase 2\|Phase 3
NCT01087476	Metropolitan Autonomous University\|Instituto Nacional de Cancerologia de Mexico	Mucositis	May 2010	Phase 2
NCT02174757	CD Pharma India Pvt. Ltd.\|Sree Mookambika Institute of Dental Sciences	Chronic Periodontitis	August 2014	Phase 3
NCT03911440	National Taiwan University Hospital	Atypical Pneumonia	November 10, 2018	Not Applicable
NCT02553083	Rabin Medical Center	Bacterial Infection Due to Helicobacter Pylori (H. Pylori)	October 22, 2015	Phase 4
NCT04234945	Ahmadu Bello University Teaching Hospital	Infertility, Female\|Pelvic Inflammatory Disease	January 13, 2020	Not Applicable
NCT00892281	Galderma Laboratories, L.P.	Rosacea	April 2009	Phase 4
NCT02913118	Qingfeng Pharmaceutical Group	Community Acquired Pneumonia	July 2016	Phase 4
NCT04153604	Methodist Health System	Cirrhosis\|Spontaneous Bacterial Peritonitis	November 4, 2019
NCT03153267	University Medical Centre Ljubljana\|University of Ljubljana School of Medicine, Slovenia	Erythema Chronicum Migrans	June 1, 2017	Not Applicable
NCT03116659	James J. Peters Veterans Affairs Medical Center	Lymphoma, T-Cell, Cutaneous	February 1, 2018	Early Phase 1
NCT03401372	Jian Li\|Peking University First Hospital\|Chinese PLA General Hospital\|Beijing Chao Yang Hospital\|West China Hospital Affiliated with Sichuan University\|Tongji Hospital Affiliated with Tongji Medical College of HUST\|Union Hospital Affiliated with Tongji Medical College of HUST\|Shanghai Changzheng Hospital\|Nanfang Hospital of Southern Medical University\|Peking Union Medical College Hospital	Amyloidosis; Systemic	April 21, 2018	Not Applicable
NCT01380496	Par Pharmaceutical, Inc.\|Anapharm	To Determine Bioequivalence Under Fed Conditions	November 1999	Phase 1
NCT03083197	University of Oxford\|Shoklo Malaria Research Unit\|Chiangrai Prachanukroh Hospital	Scrub Typhus	October 15, 2017	Phase 4
NCT00237016	Medical Corps, Israel Defense Force	Relapsing Fever, Tick-Borne\|Jarisch Herxheimer Reaction	April 2002	Phase 2\|Phase 3
NCT01308619	Galderma Laboratories, L.P.	Rosacea	April 2011	Phase 4
NCT01198912	University Hospital, Ghent	Chronic Rhinosinusitis\|Nasal Polyps	November 22, 2011	Phase 2
NCT02016365	Umeå University	Transthyretin Amyloidosis\|Cardiomyopathy	February 2012	Phase 2
NCT00783523	University of California, San Francisco	Arteriovenous Malformations\|Cavernous Angiomas\|Brain Aneurysms	March 2008	Phase 1
NCT03337932	University Medical Centre Ljubljana	Erythema Chronicum Migrans	January 1, 2018	Not Applicable
NCT00568711	Dong-Min Kim\|Chosun University Hospital	Scrub Typhus	September 2006	Not Applicable
NCT01874860	University of Louisville\|James Graham Brown Cancer Center	Colorectal Cancer\|Head and Neck Cancer	August 2013	Phase 2
NCT01171859	IRCCS Policlinico S. Matteo	Transthyretin Amyloidosis	July 2010	Phase 2
NCT01653522	The Cleveland Clinic	Migraine Disorders\|Headache, Migraine\|Migraine\|Migraine Headache\|Migraine With Aura\|Migraine Without Aura\|Headache Disorders, Primary	July 2012	Not Applicable
NCT01820910	International Extranodal Lymphoma Study Group (IELSG)	Marginal Zone Lymphoma of Ocular Adnexal	March 2013	Phase 2
NCT01323101	University of Southern California	Cystic Fibrosis	April 2008	Phase 4
NCT00829764	Teva Pharmaceuticals USA	Healthy	October 2006	Phase 1
NCT01668498	AIO-Studien-gGmbH	Ras-wildtype Colorectal Cancer	May 2011	Phase 2
NCT01030666	Peter Eickholz\|Heidelberg University\|Dr. August Wolff GmbH & Co. KG Arzneimittel\|Gaba International AG\|Goethe University	Periodontitis	April 2007	Phase 4
NCT00012688	US Department of Veterans Affairs\|Colgate-Periogard-Dentsply\|VA Office of Research and Development	Diabetes Mellitus\|Poor Glycemic Control\|Peridontal Disease		Not Applicable
NCT01885910	Derm Research, PLLC\|WFH MEDICAL, LLC	Acne Vulgaris	July 2013	Phase 4
NCT02328469	University Medical Centre Ljubljana\|Slovenian Research Agency\|University of Ljubljana School of Medicine, Slovenia\|Harvard University	Aseptic Meningitis	June 2014
NCT00355602	University of Dundee\|Tenovus Scotland	Colitis, Ulcerative	July 2006	Not Applicable
NCT02606032	Hamilton Health Sciences Corporation\|Hamilton Academic Health Sciences Organization	Ulcerative Colitis	May 2016	Phase 2
NCT01465802	Pfizer	Non Small Cell Lung Cancer (NSCLC)	December 26, 2011	Phase 2
NCT02623959	M.D. Anderson Cancer Center	Advanced Cancers\|Malignant Pleural Effusions	April 27, 2016	Phase 4
NCT03481972	IRCCS Policlinico S. Matteo	TTR Cardiac Amyloidosis	April 11, 2018	Phase 3
NCT00428818	University of Texas Southwestern Medical Center	Infection	August 2005	Not Applicable
NCT01935622	Virginia Commonwealth University	Non-ischemic Cardiomyopathy\|Systolic Heart Failure (NYHA II-III)	July 2012	Phase 2
NCT01886560	Sun Yat-sen University	Eye Burns	September 2013	Phase 2\|Phase 3
NCT04239755	Damanhour University\|Tanta University	Traumatic Brain Injury	December 15, 2019	Phase 4
NCT02204254	Centre Hospitalier Universitaire de Nice	Rosacea	March 2014	Not Applicable
NCT00837213	Stiefel, a GSK Company\|GlaxoSmithKline	Acne	August 2007	Phase 4
NCT03115177	Rush University Medical Center	Osteoarthritis	November 2015	Not Applicable
NCT03618108	Cadrock Pty. Ltd.\|Centre for Digestive Diseases, Australia	Coronary Heart Disease\|Chlamydophila Pneumoniae Infections	April 4, 2018	Phase 2
NCT03435952	M.D. Anderson Cancer Center\|BioMed Valley Discoveries, Inc\|Merck Sharp & Dohme Corp.	Malignant Neoplasm of Breast\|Malignant Neoplasms of Digestive Organs\|Malignant Neoplasms of Eye Brain and Other Parts of Central Nervous System\|Malignant Neoplasms of Female Genital Organs\|Malignant Neoplasms of Ill-defined Secondary and Unspecified Sites\|Malignant Neoplasms of Independent (Primary) Multiple Sites\|Malignant Neoplasms of Lip Oral Cavity and Pharynx\|Malignant Neoplasms of Male Genital Organs\|Malignant Neoplasms of Mesothelial and Soft Tissue\|Malignant Neoplasms of Respiratory and Intrathoracic Organs\|Malignant Neoplasms of Thyroid and Other Endocrine Glands\|Malignant Neoplasms of Urinary Tract	July 10, 2018	Phase 1
NCT01867294	Academic and Community Cancer Research United\|National Cancer Institute (NCI)	Advanced Malignant Neoplasm\|Dermatologic Complication	August 31, 2012	Phase 2
NCT01677286	Boston University	Amyloidosis	July 2012	Phase 2
NCT00511875	Thomas Gardner\|Juvenile Diabetes Research Foundation\|Milton S. Hershey Medical Center	Diabetic Retinopathy	July 2008	Phase 2
NCT04108897	Johns Hopkins University	Rosacea	September 17, 2019	Early Phase 1
NCT00631501	Kaunas University of Medicine\|University Hospital, Linkoeping	Lateral Epicondylalgia (Tennis Elbow)		Not Applicable
NCT02203682	Sun Yat-sen University	Graves Ophthalmopathy\|Graves Disease\|Eye Diseases\|Thyroid Diseases\|Endocrine System Diseases\|Eye Diseases, Hereditary\|Hyperthyroidism\|Autoimmune Diseases\|Immune System Diseases	July 2014	Phase 2
NCT02005653	Indian Council of Medical Research	Filarial; Infestation	February 2009	Phase 4
NCT03585140	Centro Dermatológico Dr. Ladislao de la Pascua	Acne Vulgaris\|Diet Modification	January 1, 2016	Not Applicable
NCT02147262	University Medical Centre Ljubljana\|University of Ljubljana School of Medicine, Slovenia\|Medical University of Vienna\|Harvard University	Chronic Atrophic Acrodermatitis	July 2013	Not Applicable
NCT02220751	University of Sao Paulo\|Fundação de Amparo à Pesquisa do Estado de São Paulo	Periodontitis\|Type 2 Diabetes Mellitus	March 2009	Phase 3
NCT01825408	University of North Carolina, Chapel Hill	Sinusitis	February 2013	Phase 4
NCT02884713	King Faisal Specialist Hospital & Research Center	GASTRITIS	June 2013	Not Applicable
NCT02726646	University of Campinas, Brazil\|Pontificia Universidade Catolica de Sao Paulo	Chronic Periodontitis	June 2015	Phase 2
NCT00883818	Samsung Medical Center	Overactive Bladder	January 2007	Phase 4
NCT00829790	Teva Pharmaceuticals USA	Healthy	October 2006	Phase 1
NCT01949233	University of Oxford\|Oxford University Hospitals NHS Trust	Marfan Syndrome	October 2013	Phase 2
NCT01518192	University Medical Centre Ljubljana\|Slovenian Research Agency	Erythema Migrans\|Post-Lyme Disease Symptoms	June 2006	Phase 4
NCT02845024	Islamic Azad University, Tehran	Diabetes Mellitus With Periodontal Disease	September 2014	Not Applicable
NCT01879930	University Hospital Inselspital, Berne	Chronic Pelvic Pain Syndrome\|Bladder Pain Syndrome	November 2012	Phase 4
NCT00041977	CollaGenex Pharmaceuticals	Acne Rosacea	June 2002	Phase 3
NCT02341209	Rochester General Hospital	Cutaneous T-cell Lymphoma\|Mycosis Fungoides\|Sezary Syndrome	February 6, 2018	Phase 2
NCT00002872	Eastern Cooperative Oncology Group\|National Cancer Institute (NCI)\|North Central Cancer Treatment Group	Metastatic Cancer	November 1996	Phase 3
NCT03162497	Medical University of Vienna	Dry Eye Syndromes\|Meibomian Gland Dysfunction	January 8, 2018	Phase 4
NCT01418742	Gesellschaft fur Medizinische Innovation ? Hamatologie und Onkologie mbH\|ClinAssess GmbH	Colorectal Carcinoma	August 2011	Phase 2
NCT00980148	National Institute of Allergy and Infectious Diseases (NIAID)	Chlamydial Infection	December 2009	Phase 3
NCT03342456	The Third Xiangya Hospital of Central South University\|Livzon Pharmaceutical Group Inc.\|Yung Shin Pharm. Ind. Co., Ltd.	Duodenal Ulcer Due to Helicobacter Pylori	December 13, 2017	Phase 4
NCT04310930	The University of Queensland\|Australian Government Department of Health\|Children´s Hospital Foundation\|Cystic Fibrosis Foundation\|Newcastle University\|Griffith University\|Erasmus Medical Center\|Monash University\|University of Copenhagen\|Hôpital Cochin\|South Australian Health and Medical Research Institute\|University of Melbourne\|James Cook University, Queensland, Australia\|Murdoch Childrens Research Institute	Pulmonary Disease Due to Mycobacteria (Diagnosis)	March 2020	Phase 2\|Phase 3
NCT03709459	Kirby Institute\|South Australian Health and Medical Research Institute\|Monash University	STIs Prevention	December 17, 2019
NCT04067011	Emergent BioSolutions\|Biomedical Advanced Research and Development Authority	Anthrax	August 12, 2019	Phase 2
NCT02844634	British Columbia Centre for Disease Control	HIV\|Syphilis	May 15, 2018	Phase 4
NCT00647959	Mylan Pharmaceuticals	Healthy	March 2006	Phase 1
NCT00170222	Medical Center Alkmaar	Chronic Obstructive Pulmonary Disease	July 2002	Phase 4
NCT03075891	Galderma	Rosacea	July 5, 2017	Phase 4
NCT00031499	National Institute of Allergy and Infectious Diseases (NIAID)	Syphilis	June 2000	Phase 3
NCT01205464	Linkoeping University	Fatigue\|Radicular Pain\|Cognitive Dysfunction\|Paresthesia\|Paresis	February 2005	Not Applicable
NCT01301586	Nexgen Dermatologics, Inc.	ACNE VULGARIS	November 2010	Phase 1\|Phase 2
NCT02305940	Imperial College London	Chronic Obstructive Pulmonary Disease (COPD)	July 2014	Phase 3
NCT00351182	Dong-Min Kim\|Chosun University Hospital	Scrub Typhus	September 2005	Phase 3
NCT03334682	Nantes University Hospital	Acne Vulgaris	January 31, 2018	Phase 3
NCT01788215	University of Rochester	Polycystic Ovarian Syndrome (PCOS)\|Irregular Menstrual Cycles\|Androgen Excess	November 2010	Phase 3
NCT03076281	Sidney Kimmel Cancer Center at Thomas Jefferson University\|Thomas Jefferson University	Larynx\|LIP\|Oral Cavity\|Pharynx	April 3, 2017	Phase 2
NCT00439166	Hamilton Health Sciences Corporation\|The Physicians´ Services Incorporated Foundation\|McMaster University	Alzheimer´s Disease	February 2007	Phase 3
NCT02463942	University Medical Centre Ljubljana\|University of Ljubljana School of Medicine, Slovenia	Tick-borne Encephalitis	September 2014	Not Applicable
NCT00803842	Northwestern University	Non Small Cell Lung Cancer	October 2008	Not Applicable
NCT02086591	University of Rochester	Adult Diffuse Large B-Cell Lymphoma\|Mantle Cell Lymphoma Recurrent\|Lymphoma, Follicular\|Marginal Zone B-Cell Lymphoma\|Malignant Lymphoma - Lymphoplasmacytic\|Waldenstrom Macroglobulinemia\|Small Lymphocytic Lymphoma\|Chronic Lymphocytic Leukemia (CLL)\|T-Cell Lymphoma	March 2014	Phase 2
NCT03980223	University of California, San Francisco\|University of Washington\|National Institute of Allergy and Infectious Diseases (NIAID)\|Mayne Pharma International Pty Ltd\|San Francisco Department of Public Health	Gonorrhea\|Chlamydia\|Syphilis	November 26, 2019	Phase 4
NCT00355459	University of Texas Southwestern Medical Center	Dry Eye Syndrome	August 2005	Not Applicable
NCT01254799	Omar Mamdouh Shaaban\|Assiut University	Uterine Hemorrhage	January 2008	Phase 3
NCT01547325	NanoSHIFT LLC\|United States Department of Defense	Dehisced Surgical Wounds	May 2012	Not Applicable
NCT00653380	Par Pharmaceutical, Inc.\|Anapharm	To Determine Bioequivalence Under Fasting Conditions	September 1999	Phase 1
NCT00635609	Warner Chilcott	Acne Vulgaris	March 2008	Phase 4
NCT03765931	Institut de Recherche pour le Developpement	Fever	July 2016	Phase 4
NCT01160640	Harold Wiesenfeld\|National Institute of Allergy and Infectious Diseases (NIAID)\|University of Pittsburgh	Pelvic Inflammatory Disease	November 2010	Phase 2
NCT01756833	University of Maryland, Baltimore\|National Institute on Aging (NIA)	Aneurysm	May 2013	Phase 2
NCT00688064	Galderma	Severe Acne Vulgaris	August 2008	Phase 3
NCT01320033	Galderma	Acne Vulgaris	March 29, 2011	Phase 2
NCT03397004	St. Michael´s Hospital, Toronto\|Barrow Neurological Institute\|Duke University\|Feinstein Institute for Medical Research\|University of Pittsburgh\|Sunnybrook Health Sciences Centre	Hereditary Hemorrhagic Telangiectasia (HHT)	September 12, 2018	Phase 2
NCT01635530	Turku University Hospital	Lyme Neuroborreliosis	August 2012	Phase 4
NCT03727620	Mohammed V Souissi University	Aggressive Periodontitis	January 6, 2014	Phase 1\|Phase 2
NCT02688738	Rothman Institute Orthopaedics	Propionibacterium	March 2015	Not Applicable
NCT00358462	University of Washington\|National Institute of Allergy and Infectious Diseases (NIAID)	Urethritis	January 2007	Phase 3
NCT02864550	British Columbia Centre for Disease Control	Syphilis\|Sexually Transmitted Infections	August 15, 2019	Phase 4
NCT01595594	University of Sao Paulo\|Fundação de Amparo à Pesquisa do Estado de São Paulo	Periodontal Disease\|Type 2 Diabetes	March 2010	Phase 3
NCT00964834	PharmAthene, Inc.\|National Institutes of Health (NIH)\|Medarex\|Quintiles, Inc.\|Department of Health and Human Services	Anthrax	July 2009	Phase 1
NCT01809444	Sun Yat-sen University	Thyroid Associated Opthalmopathies	November 2012	Phase 2\|Phase 3
NCT01590082	M.D. Anderson Cancer Center\|National Institutes of Health (NIH)\|National Cancer Institute (NCI)	Melanoma	November 2012	Phase 1\|Phase 2
NCT00207584	Centers for Disease Control and Prevention	Mycoplasma Pneumoniae	January 1994	Not Applicable
NCT00775177	Ranbaxy Laboratories Limited\|Ranbaxy Inc.	Healthy	June 2005	Not Applicable
NCT03462329	University Medical Centre Ljubljana	Erythema Migrans	June 1, 2018	Not Applicable
NCT00000403	Indiana University\|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)\|National Institute on Aging (NIA)	Osteoarthritis	September 1996	Phase 3
NCT03508232	University of Alberta\|Royal Alexandra Hospital	ST Segment Elevation Myocardial Infarction\|Heart Failure	January 6, 2020	Phase 2
NCT02553473	Sorlandet Hospital HF	Neuroborreliosis, Borrelia Burgdorferi	October 2015	Phase 3
NCT02207556	Medical College of Wisconsin	Primary Systemic Amyloidosis	October 1, 2014	Phase 2
NCT01783106	Royal Liverpool University Hospital\|National Association for Colitis and Crohn´s Disease\|National Institute for Health Research, United Kingdom	Crohn´s Disease	February 1, 2014	Phase 2
NCT00353743	Hospital de Clinicas de Porto Alegre	Abortion, Septic	May 2006	Not Applicable
NCT01727973	Sun Yat-sen University	Graves Ophthalmopathy\|Graves Disease\|Eye Diseases\|Thyroid Diseases\|Endocrine System Diseases\|Eye Diseases, Hereditary\|Hyperthyroidism\|Autoimmune Diseases\|Immune System Diseases	October 2012	Phase 1\|Phase 2
NCT00857038	Medical Center Alkmaar\|Leiden University Medical Center\|University of Amsterdam	Chronic Obstructive Pulmonary Disease\|Inflammation\|Pulmonary Emphysema	April 2009	Phase 4
NCT02774993	National University Hospital, Singapore\|Tan Tock Seng Hospital\|National University, Singapore\|A*Star	Tuberculosis	September 2015	Phase 2
NCT03474458	IRCCS Policlinico S. Matteo	Cardiac AL Amyloidosis	February 11, 2019	Phase 2\|Phase 3
NCT02874430	Sidney Kimmel Cancer Center at Thomas Jefferson University\|Thomas Jefferson University	Breast Carcinoma\|Endometrial Clear Cell Adenocarcinoma\|Endometrial Serous Adenocarcinoma\|Uterine Corpus Cancer\|Uterine Corpus Carcinosarcoma	June 8, 2016	Phase 2
NCT00016835	University of Michigan\|National Institute of Dental and Craniofacial Research (NIDCR)	Periodontal Disease\|Diabetes Mellitus, Type 2	October 17, 2001	Phase 2
NCT00064766	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Endometrial Bleeding\|Periodontal Disease	February 2003	Phase 4
NCT00803452	University of Louisville	Blepharitis	July 2008	Phase 4
NCT01434173	Bayer\|RTI Health Solutions	Drug-Induced Liver Injury	July 2001
NCT00126204	Barnes-Jewish Hospital	Aortic Aneurysm	March 2004	Not Applicable
NCT01917721	Hawaii Pacific Health	Kawasaki Disease\|Coronary Aneurysm	October 2013	Phase 2
NCT02775695	Medical College of Wisconsin	Resectable Pancreatic Cancer	April 3, 2017	Phase 2
NCT03824340	Aljazeera Hospital	Infertility	January 30, 2019	Not Applicable
NCT01847976	Ottawa Hospital Research Institute\|Canadian Breast Cancer Foundation	Pain	August 2013	Phase 2
NCT02850913	Makerere University\|University of Oxford	Seizures	September 5, 2016	Phase 2
NCT00764361	NanoSHIFT LLC	Diabetic Foot Ulcer	January 2009	Phase 2
NCT02036528	Royer Biomedical, Inc.	Diabetic Foot Ulcers	January 2014	Phase 1\|Phase 2
NCT01661985	Ostergotland County Council, Sweden\|Statens Serum Institut	Urethritis\|Cervicitis\|Genital Mycoplasma Infection\|Chlamydia Trachomatis	February 2010	Phase 4
NCT01380483	Par Pharmaceutical, Inc.\|Anapharm	To Determine Bioequivalence Under Fasting Conditions	January 2000	Phase 1
NCT00648180	Mylan Pharmaceuticals	Healthy	July 2005	Phase 1
NCT01426269	Galderma Laboratories, L.P.	Rosacea	September 2011	Phase 4
NCT02753426	University of California, San Francisco	Chronic Kidney Disease\|Cardiorenal Syndrome	April 2016	Phase 1
NCT02583282	Postgraduate Institute of Medical Education and Research	Malignant Pleural Effusion	August 1, 2015	Not Applicable
NCT02927496	The Task Force for Global Health\|United States Agency for International Development (USAID)	Lymphedema\|Lymphatic Filariasis\|Filariasis	June 19, 2018	Phase 3
NCT00652795	Par Pharmaceutical, Inc.\|Anapharm	To Determine Bioequivalence Under Fasting Conditions	July 2004	Phase 1
NCT03956212	University Medical Centre Ljubljana\|University of Ljubljana School of Medicine, Slovenia	Erythema Migrans	June 1, 2017	Not Applicable
NCT00855595	Bayer	Papulopustular Rosacea	February 2009	Phase 4
NCT03457636	Derm Research, PLLC	Acne	March 19, 2018	Phase 4
NCT02894268	Sir Run Run Shaw Hospital	Helicobacter Pylori Infection	February 2016	Phase 4
NCT03465774	M.D. Anderson Cancer Center\|National Cancer Institute (NCI)	Malignant Pleural Effusion	March 8, 2018	Early Phase 1