English

Factory Cheap Hot Doxycycline Hyclate 100mg For Chlamydia - Venetoclax 1257044-40-8 – CPF

Factory Cheap Hot Doxycycline Hyclate 100mg For Chlamydia - Venetoclax 1257044-40-8 – CPF Featured Image
  • Factory Cheap Hot Doxycycline Hyclate 100mg For Chlamydia - Venetoclax 1257044-40-8 – CPF

Short Description:


Product Detail

Product Tags

Related Video

Feedback (2)

We rely upon strategic thinking, constant modernisation in all segments, technological advances and of course upon our employees that directly participate in our success for Monodox Doxycycline Monohydrate 100mg, Niraparib Tosylate Hydrate, Pregabalin, We, with open arms, invite all interested buyers to visit our website or contact us directly for further information.
Factory Cheap Hot Doxycycline Hyclate 100mg For Chlamydia - Venetoclax 1257044-40-8 – CPF Detail:

维奈妥拉 Venetoclax 1257044-40-8 In-House
    VCL-6A 98549-88-3 In-House
    VCL-7A 1235865-75-4 In-House
    VCLM2 1228780-72-0 In-House
    VCLM2-2HCl 1628047-87-9 In-House
    VCLM3 1228779-96-1 In-House

Generic Name: venetoclax (ven ET oh klax)
Brand Name: Venclexta, Venclexta Starting Pack

Venetoclax is used to treat chronic lymphocytic leukemia or small lymphocytic leukemia in adults. Venetoclax is used alone or in combination with other cancer medicines to treat these conditions.

Venetoclax is used in combination with azacitidine, decitabine, or cytarabine to treat acute myeloid leukemia. This combination is for use in adults who are 75 years or older, or who cannot use standard chemotherapy due to other medical conditions.

Venetoclax is sometimes given after other treatments have failed.

Venetoclax may also be used for purposes not listed in this medication guide.

Description

Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy.

In Vitro

Venetoclax (ABT-199) potently kills FL5.12-BCL-2 cells (EC50=4 nM), Venetoclax (ABT-199) shows much weaker activity against FL5.12-BCL-XL cells (EC50=261 nM). ABT-199 also shows selectivity in cellular mammalian two-hybrid assays, where it disrupts BCL-2-BIM complexes (EC50=3 nM) but is much less effective against BCL-XL-BCL-XS (EC50=2.2 μM) or MCL-1-NOXA complexes.

After a single oral dose of 12.5 mg per kg body weight in xenografts derived from RS4;11 cells (ALL), Venetoclax (ABT-199) causes a maximal tumor growth inhibition (TGImax) of 47% (P<0.001) and tumor growth delay (TGD) of 26% (P<0.05)[1].

Treatment of established xenografted (a mouse xenograft model of the T-ALL cell line LOUCY) tumors with Venetoclax (ABT-199) 100 mg/kg for 4 days results in a significant reduction of leukemic burden.

Storage

Powder

-20°C

 3 years

4°C

 2 years
In solvent

-80°C

 6 months

-20°C

 1 month

Chemical structure

Venetoclax 1257044-40-8

2018 GMP-2
原料药GMP证书201811（captopril ,thalidomide etc）
GMP-of-PMDA-in-Chanyoo-平成28年08月03日　Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

OUR STRENGTH

Quality management1

Proposal 18 Quality Consistency Evaluation projects which have approved 4, and 6 projects are under approving.

Quality management2

Advanced international quality management system has laid solid foundation for sales.

Quality management3

Quality supervision runs through the whole life cycle of the product to ensure the quality and therapeutic effect. 

Quality management4

Professional Regulatory Affairs team supports the quality demands during the application and registration.


VIEW MORE


VIEW MORE

International cooperation
International cooperation
Domestic cooperation
Domestic cooperation

Product detail pictures:

Factory Cheap Hot Doxycycline Hyclate 100mg For Chlamydia - Venetoclax 1257044-40-8 – CPF detail pictures

Related Product Guide:
Our well-equipped facilities and excellent excellent management throughout all stages of creation enables us to guarantee total buyer satisfaction for Factory Cheap Hot Doxycycline Hyclate 100mg For Chlamydia - Venetoclax 1257044-40-8 – CPF , The product will supply to all over the world, such as: Luxemburg, Bandung, Sacramento, If you need to have any of our merchandise, or have other items to be produced, make sure you send us your inquiries, samples or in depth drawings. Meanwhile, aiming to develop into an international enterprise group, we look forward to receiving offers for joint ventures and other cooperative projects.
    • The sales manager has a good English level and skilled professional knowledge, we have a good communication. He is a warm and cheerful man, we have a pleasant cooperation and we became very good friends in private.
    5 Stars By Agustin from French - 2017.08.16 13:39
    Company director has very rich management experience and strict attitude, sales staff are warm and cheerful, technical staff are professional and responsible,so we have no worry about product,a nice manufacturer.
    5 Stars By Hilda from US - 2017.11.20 15:58
    Write your message here and send it to us

    Products categories