English

Factory Free sample Olmesartan Amlodipine Hydrochlorothiazide - Hydrochlorothiazide – CPF

Factory Free sample Olmesartan Amlodipine Hydrochlorothiazide - Hydrochlorothiazide – CPF Featured Image
  • Factory Free sample Olmesartan Amlodipine Hydrochlorothiazide - Hydrochlorothiazide – CPF

Short Description:


Product Detail

Product Tags

Related Video

Feedback (2)

We will devote ourselves to providing our esteemed customers with the most enthusiastically thoughtful services for Doxycycline Hyclate For Cats, Fenofibrate Rosuvastatin Calcium, Doxycycline Monohydrate 100 Mg Oral Capsule, We have now deep cooperation with hundreds of factories all over China. The goods we give can match with your different calls for. Choose us, and we won't make you regret!
Factory Free sample Olmesartan Amlodipine Hydrochlorothiazide - Hydrochlorothiazide – CPF Detail:

Description

Hydrochlorothiazide (HCTZ), an orally active diuretic drug of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect.

Background

Hydrochlorothiazide is a diuretic drug of the thiazide class.

In Vitro

Hydrochlorothiazide belongs to thiazide class of diuretics. It reduces blood volume by acting on the kidneys to reduce sodium (Na) reabsorption in the distal convoluted tubule. The major site of action in the nephron appears on an electroneutral Na+-Cl co-transporter by competing for the chloride site on the transporter. By impairing Na transport in the distal convoluted tubule, hydrochlorothiazide induces a natriuresis and concomitant water loss. Thiazides increase the reabsorption of calcium in this segment in a manner unrelated to sodium transport. Additionally, by other mechanisms, Hydrochlorothiazide is believed to lower peripheral vascular resistance.

Hydrochlorothiazide (HCTZ; orally bygavage; 12.5 mg/kg/d; 8 weeks) has improved cardiac function, reduced cardiac interstitial fibrosis and collagen volume fraction, decreased expression of AT1, TGF-β and Smad2 in the cardiac tissues in adult male Sprague Dawley rats. In addition, hydrochlorothiazide reduces plasma angiotensin II and aldosterone levels. Furthermore, hydrochlorothiazide inhibits angiotensin II-induced TGF-β1 and Smad2 protein expression in the neonatal rat ventricular fibroblasts.

Chemical structure

Hydrochlorothiazide

2018 GMP-2
原料药GMP证书201811（captopril ,thalidomide etc）
GMP-of-PMDA-in-Chanyoo-平成28年08月03日　Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

OUR STRENGTH

Quality management1

Proposal 18 Quality Consistency Evaluation projects which have approved 4, and 6 projects are under approving.

Quality management2

Advanced international quality management system has laid solid foundation for sales.

Quality management3

Quality supervision runs through the whole life cycle of the product to ensure the quality and therapeutic effect. 

Quality management4

Professional Regulatory Affairs team supports the quality demands during the application and registration.


VIEW MORE


VIEW MORE

International cooperation
International cooperation
Domestic cooperation
Domestic cooperation

Product detail pictures:

Factory Free sample Olmesartan Amlodipine Hydrochlorothiazide - Hydrochlorothiazide – CPF detail pictures

Related Product Guide:
Our business puts emphasis over the administration, the introduction of talented staff, plus the construction of employees building, striving hard to boost the standard and liability consciousness of staff members. Our corporation successfully attained IS9001 Certification and European CE Certification of Factory Free sample Olmesartan Amlodipine Hydrochlorothiazide - Hydrochlorothiazide – CPF , The product will supply to all over the world, such as: Iran, Greece, Peru, As a way to use the resource on the expanding info in international trade, we welcome prospects from everywhere on the web and offline. In spite on the high quality objects we offer you, effective and satisfying consultation service is supplied by our qualified after-sale service group. Item lists and in depth parameters and any other info weil be sent to you timely for the inquiries. So you should make contact with us by sending us emails or call us when you've got any questions about our organization. ou could also get our address information from our site and come to our enterprise. We get a field survey of our merchandise. We're confident that we are going to share mutual accomplishment and create solid co-operation relations with our companions within this market place. We're seeking forward for your inquiries.
    • Product variety is complete, good quality and inexpensive, the delivery is fast and transport is security, very good, we are happy to cooperate with a reputable company!
    5 Stars By trameka milhouse from Russia - 2017.09.16 13:44
    This company has the idea of "better quality, lower processing costs, prices are more reasonable", so they have competitive product quality and price, that's the main reason we chose to cooperate.
    5 Stars By Esther from Juventus - 2017.07.28 15:46
    Write your message here and send it to us

    Products categories