Factory supplied Doxycycline Hyclate And Monohydrate - Agomelatine – CPF
Factory supplied Doxycycline Hyclate And Monohydrate - Agomelatine – CPF Detail:
Background
Agomelatine is an agonist of melatonin receptors and an antagonist of the serotonin 5-HT2C receptor with Ki values of 0.062nM and 0.268nM and IC50 value of 0.27μM, respectively for MT1, MT2 and 5-HT2C [1].
Agomelatine is a unique antidepressant and is developed for treatment of major depressive disorder (MDD). Agomelatine is selective against 5-HT2C. It shows low affinities to cloned human 5-HT2A and 5-HT1A. For melatonin receptors, agomelatine shows similar affinities to cloned human MT1 and MT2 with Ki values of 0.09nM and 0.263nM, respectively. In the in vivo studies, agomelatine causes increase of dopamine and noradrenaline levels via blocking the inhibitory input of 5-HT2C. Moreover, the administration of agomelatine counteractes the stress-induced decrease in sucrose consumption in a rat model of depression. Besides that, agomelatine exerts alleviated anxiety efficacy in a rodent model of anxiety [1].
References:
[1] Zupancic M, Guilleminault C. Agomelatine. CNS drugs, 2006, 20(12): 981-992.
Chemical structure
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Our progress depends about the advanced products ,fantastic talents and continuously strengthened technology forces for Factory supplied Doxycycline Hyclate And Monohydrate - Agomelatine – CPF , The product will supply to all over the world, such as: Costa Rica, Amman, Lebanon, To win customers' confidence, Best Source has set up a strong sales and after-sales team to deliver the best product and service. Best Source abides by the idea of "Grow with customer" and philosophy of "Customer-oriented" to achieve cooperation of mutual trust and benefit. Best Source will always stand ready to cooperate with you. Let's grow together!
By Mildred from Tajikistan - 2018.09.12 17:18
Although we are a small company, we are also respected. Reliable quality, sincere service and good credit, we are honored to be able to work with you!
By Meroy from Greek - 2018.06.05 13:10