Factory wholesale Favipiravir Supplier - Thalidomide – CPF
Factory wholesale Favipiravir Supplier - Thalidomide – CPF Detail:
Background
Thalidomide was introduced as a sedative drug,immunomodulatory agent and also is investigated for treating symptoms of many cancers.Thalidomide inhibits an E3 ubiquitin ligase, which is a CRBN-DDB1-Cul4A complex.
Description
Thalidomide is initially promoted as a sedative, inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ∼250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties.
In Vitro
Thalidomide is initially promoted as a sedative, has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties, and targets cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ∼250 nM[1]. Thalidomide (50 μg/mL) potentiates the anti-tumor activity of icotinib against the proliferation of both PC9 and A549 cells, and this effect is correlated with apoptosis and cell migration. In addition, Thalidomide and icotinib inhibits the EGFR and VEGF-R2 pathways in PC9 cells[3].
Thalidomide (100 mg/kg, p.o.) inhibits the collagen deposition, down-regulates the mRNA expression level of α-SMA and collagen I, and significantly reduces the pro-inflammatory cytokines in RILF mice. Thalidomide alleviates RILF via suppression of ROS and down-regulation of TGF-β/Smad pathway dependent on Nrf2 status[2]. Thalidomide (200 mg/kg, p.o.) combined with icotinib shows synergistic anti-tumor effects in nude mice bearing PC9 cells, suppressing tumor growth and promoting tumor death[3].
Storage
Powder |
-20°C |
3 years |
4°C |
2 years | |
In solvent |
-80°C |
6 months |
-20°C |
1 month |
Chemical structure
Proposal 18 Quality Consistency Evaluation projects which have approved 4, and 6 projects are under approving.
Advanced international quality management system has laid solid foundation for sales.
Quality supervision runs through the whole life cycle of the product to ensure the quality and therapeutic effect.
Professional Regulatory Affairs team supports the quality demands during the application and registration.
VIEW MORE
VIEW MORE
International cooperation
Domestic cooperation
Product detail pictures:
Related Product Guide:
We are also specializing in improving the things management and QC method in order that we could retain terrific edge inside the fiercely-competitive small business for Factory wholesale Favipiravir Supplier - Thalidomide – CPF , The product will supply to all over the world, such as: Canada, Buenos Aires, Lithuania, Our qualified engineering team will usually be prepared to serve you for consultation and feedback. We've been able to also deliver you with absolutely free samples to meet your needs. Best efforts might be made to offer you the ideal service and items. For anyone who is interested in our company and products, be sure to make contact with us by sending us emails or contact us right away. In order to know our solutions and organization. ar more, you can come to our factory to determine it. We are about to usually welcome guests from around the globe to our corporation. o create small business relations with us. Please genuinely feel no cost to speak to us for enterprise. nd we believe we have been gonna share the most effective trading practical experience with all our merchants.
By Kitty from Tunisia - 2017.11.01 17:04
The product manager is a very hot and professional person, we have a pleasant conversation, and finally we reached a consensus agreement.
By Laura from Borussia Dortmund - 2017.09.26 12:12