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Leading Manufacturer for Bictegravir Cost - Ledipasvir Actone /PVP – CPF
雷迪帕韦丙酮/聚维酮 Ledipasvir actone/PVP 1256388-51-8 In-House LPSM1 1256387-87-7 In-House LPSM1-5 291775-59-2 In-House LPSM2 1129634-44-1 In-House LPS-6 1441670-89-8 In-House Ledipasvir acetone (GS-5885 acetone) is the active ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon. In Vitro Ledipasvir acetone is considered the active ingredient, which ... -
100% Original Doxycycline Hyclate 100mg For Sinus - Dabigatran Etexilate Mesylate – CPF
Description Dabigatran etexilate mesylate (BIBR 1048MS) is an orally active prodrug of Dabigatran. Dabigatran etexilate mesylate has anticoagulant effects and is used for the prophylaxis of venousthromboembolism and stroke due to atrial fibrillation. Background Description: IC50 Value: 4.5nM (Ki); 10nM(Thrombin-induced platelet aggregation) [1] Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI) undergoing advanced clinical development as its orally active prodrug,dabiga... -
Super Lowest Price Doxycycline Mono En Español - Atorvastatin Calcium – CPF
Background Atorvastatin Calcium is a potent inhibitor of HMG-CoA reductase with IC50 value of 150 nM[1]. HMG-CoA reductase is the key enzyme of the mevalonate pathway which produces cholesterol. HMG-CoA is the rate-limiting enzyme and is important for lowering the blood cholesterol levels. HMG-CoA reductase is located in the endoplasmic reticulum and contains eight transmembrane domains. The inhibitors of HMG-CoA reductase can induce the LDL (low density lipoprotein) receptors expression in t... -
factory low price Sacubitril Supplier - Niraparib 1038915-60-4 – CPF
Description Niraparib (MK-4827) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. Niraparib leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity. In Vitro Niraparib (MK-4827) inhibits PARP activity with EC50=4 nM and EC90=45 nM in a whole cell assay. MK-4827 inhibits proliferation of cancer cells with mutant BRCA-1 and BRCA-2 with CC50 in the 10-100 nM range. MK-4827 displays exce... -
Professional China Doxycycline Mono And Alcohol - Niraparib 1038915-60-4 – CPF
Description Niraparib (MK-4827) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. Niraparib leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity. In Vitro Niraparib (MK-4827) inhibits PARP activity with EC50=4 nM and EC90=45 nM in a whole cell assay. MK-4827 inhibits proliferation of cancer cells with mutant BRCA-1 and BRCA-2 with CC50 in the 10-100 nM range. MK-4827 displays exce... -
China Wholesale Rosuvastatin Calcium Tablets 10mg Suppliers - Canagliflozin – CPF
Background Canagliflozin is a novel, potent, and highly selective sodium glucose co-transporter (SGLT) 2 inhibitor [1]. It has been proved that Canagliflozin can increase urine glucose excretion by reducing the renal glucose threshold and by decreasing the filtered glucose re-absorption [2]. Canagliflozin has been shown to inhibit the Na+-mediated 14C-AMG intakes in CHO-hSGLT2, CHO-rat SGLT2 and CHO-mouse SGLT2 with IC50 values of 4.4, 3.7 and 2.0 nM, respectively [1]. Canagliflozin has been ... -
Factory Outlets Sofosbuvir People Also Search For - Ribociclib 1374639-75-4 – CPF
Description Ribociclib (LEE01) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex. In Vitro Treating a panel of 17 neuroblastoma cell lines with Ribociclib (LEE011) across a four-log dose range (10 to 10,000 nM). Treatment with Ribociclib significantly inhibits substrate adherent growth relative to the control in 12 of the 17 neuroblastoma cell lines examined (mean IC50=306±68 nM, con... -
2020 Latest Design Apo Hydrochlorothiazide - Rivaroxaban – CPF
Background Rivaroxaban, 5-chloro-N-[[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl]thiophene-2-carboxamide, is a potent small-molecule inhibitor of factor Xa which is a coagulation factor at a critical juncture in the blood coagulation pathway resulting in the generation of thrombin and the formation of clot. Rivaroxaban binds to the Tyr288 in S1 pocket of factor Xa through the interaction of Tyr288 and the chlorine substituent of the chlorothiophene moiety. The inhi... -
New Fashion Design for Doxycycline Hyclate 100mg Tablets - Sacubitril Hemicalcium – CPF
沙库比曲半钙盐 Sacubitril Hemicalcium 1369773-39-6 In-House 沙库比曲钠盐 149690-05-1 In-House LCZ-4 1426129-50-1 In-House LCZ-7 1012341-48-8 In-House LCZ-8 1012341-50-2 In-House LCZ-9 149690-12-0 In-House Background AHU-377 hemicalcium salt is a hemicalcium salt form of AHU-377. It is an inhibitor of neprilysin with IC50 value of 5 nM [1]. AHU-377 and the angiotensin II AT1 receptor antagonist valsartan compose LCZ696 in a 1:1 molar rati... -
Cheap price Telaprevir Supplier - Canagliflozin – CPF
Background Canagliflozin is a novel, potent, and highly selective sodium glucose co-transporter (SGLT) 2 inhibitor [1]. It has been proved that Canagliflozin can increase urine glucose excretion by reducing the renal glucose threshold and by decreasing the filtered glucose re-absorption [2]. Canagliflozin has been shown to inhibit the Na+-mediated 14C-AMG intakes in CHO-hSGLT2, CHO-rat SGLT2 and CHO-mouse SGLT2 with IC50 values of 4.4, 3.7 and 2.0 nM, respectively [1]. Canagliflozin has been ... -
2020 New Style Triamterene And Hydrochlorothiazide - Venetoclax 1257044-40-8 – CPF
维奈妥拉 Venetoclax 1257044-40-8 In-House VCL-6A 98549-88-3 In-House VCL-7A 1235865-75-4 In-House VCLM2 1228780-72-0 In-House VCLM2-2HCl 1628047-87-9 In-House VCLM3 1228779-96-1 In-House Generic Name: venetoclax (ven ET oh klax) Brand Name: Venclexta, Venclexta Starting Pack Venetoclax is used to treat chronic lymphocytic leukemia or small lymphocytic leukemia in adults. Venetoclax is used alone or in combination with other cancer medicines to trea... -
PriceList for Atenolol Hydrochlorothiazide - Ezetimibe – CPF
Background Ezetimibe is a potent and novel inhibitor of cholesterol absorption [1]. Cholesterol is a lipid molecule and is required to build and maintain membranes structural integrity and fluidity. Also, it serves as a precursor of vitamin D, bile acids and steroid hormones. In differentiated Caco-2 cells incubated with a carotenoid (1 μM), ezetimibe (10 mg/L) inhibited carotenoid transport with 50% inhibition for ɑ-carotene and β-carotene. Also, it inhibited the transport of β-cryptoxanthin...
