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2020 High quality Ledipasvir - Agomelatine – CPF
Background Agomelatine is an agonist of melatonin receptors and an antagonist of the serotonin 5-HT2C receptor with Ki values of 0.062nM and 0.268nM and IC50 value of 0.27μM, respectively for MT1, MT2 and 5-HT2C [1]. Agomelatine is a unique antidepressant and is developed for treatment of major depressive disorder (MDD). Agomelatine is selective against 5-HT2C. It shows low affinities to cloned human 5-HT2A and 5-HT1A. For melatonin receptors, agomelatine shows similar affinities to cloned hu... -
Best Price on Sofosbuvir 400 - Ticagrelor – CPF
Background Ticagrelor is a novel antagonist of the P2Y12 receptor [1]. Ticagrelor has been reported to inhibit the prothrombotic effects of ADP on the platelet by against the P2Y12 receptor. Ticagrelor has shown the complete inhibition of platelet aggregation ex vivo. In addition Ticagrelor has suggested a dose-dependent inhibition of platelet aggregation in human being. Apart from these, Ticagrelor has also demonstrated an orally, actively, reversibly binding antagonist. Unlike other inhibit... -
Factory Supply Interdoxin 100 Doxycycline Hyclate - Dabigatran Etexilate Mesylate – CPF
Description Dabigatran etexilate mesylate (BIBR 1048MS) is an orally active prodrug of Dabigatran. Dabigatran etexilate mesylate has anticoagulant effects and is used for the prophylaxis of venousthromboembolism and stroke due to atrial fibrillation. Background Description: IC50 Value: 4.5nM (Ki); 10nM(Thrombin-induced platelet aggregation) [1] Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI) undergoing advanced clinical development as its orally active prodrug,dabiga... -
Super Purchasing for Sofosbuvir Tablets - Canagliflozin – CPF
Background Canagliflozin is a novel, potent, and highly selective sodium glucose co-transporter (SGLT) 2 inhibitor [1]. It has been proved that Canagliflozin can increase urine glucose excretion by reducing the renal glucose threshold and by decreasing the filtered glucose re-absorption [2]. Canagliflozin has been shown to inhibit the Na+-mediated 14C-AMG intakes in CHO-hSGLT2, CHO-rat SGLT2 and CHO-mouse SGLT2 with IC50 values of 4.4, 3.7 and 2.0 nM, respectively [1]. Canagliflozin has been ... -
Hot sale Factory Folic Acid - LOXO-101 1223403-58-4 – CPF
Background IC50: low nanomolar range for inhibition of all TRK family members LOXO-101 is a tropomyosin receptor kinases (TRK) inhibitor. The TRK family of neurotrophin receptors and their neurotrophin ligands regulate neuron growth, differentiation and survival. In vitro: In previous study, LOXO-101 was evaluated for off-target kinase enzyme inhibition against a panel of non-TRK kinases at a concentration of 1,000 nM and ATP concentrations around the Km. Results showed that LOXO-101 had grea... -
Good User Reputation for Doxycycline Monohydrate For Rosacea - Sacubitril Hemicalcium – CPF
沙库比曲半钙盐 Sacubitril Hemicalcium 1369773-39-6 In-House 沙库比曲钠盐 149690-05-1 In-House LCZ-4 1426129-50-1 In-House LCZ-7 1012341-48-8 In-House LCZ-8 1012341-50-2 In-House LCZ-9 149690-12-0 In-House Background AHU-377 hemicalcium salt is a hemicalcium salt form of AHU-377. It is an inhibitor of neprilysin with IC50 value of 5 nM [1]. AHU-377 and the angiotensin II AT1 receptor antagonist valsartan compose LCZ696 in a 1:1 molar rati... -
Good Quality Doxycycline Monohydrate - Ledipasvir Actone /PVP – CPF
雷迪帕韦丙酮/聚维酮 Ledipasvir actone/PVP 1256388-51-8 In-House LPSM1 1256387-87-7 In-House LPSM1-5 291775-59-2 In-House LPSM2 1129634-44-1 In-House LPS-6 1441670-89-8 In-House Ledipasvir acetone (GS-5885 acetone) is the active ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon. In Vitro Ledipasvir acetone is considered the active ingredient, which ... -
Super Purchasing for Pregabalin Indication - Velpatasvir(PVP) – CPF
Foreign Names Velpatasvirum (Latin) Velpatasvir (German) Velpatasvir (French) Velpatasvir (Spanish) Generic Names Velpatasvir (OS: USAN) GS-5816 (IS) UNII-KCU0C7RS7Z (IS) Multi-ingredient medications containing velpatasvir:sofosbuvir/velpatasvir systemic Brand names: Epclusa Drug class(es): antiviral combinations Sofosbuvir/velpatasvir systemic is used in the treatment of:Hepatitis C sofosbuvir/velpatasvir/voxilaprevir systemic Brand names: Vosevi Drug class(es): antiviral combinations Sofosb... -
China Cheap price Rosuvastatin Supplier - Chlorothiazide – CPF
Background Chlorothiazide is an inhibitor of carbonic anhydrase and is slightly less potent than acetazolamide. This compound has been shown to block reabsorption of sodium and chloride ions. Description Chlorothiazide is a diuretic and antihypertensive. (IC50=3.8 mM) Target: Others Chlorothiazide sodium (Diuril) is a diuretic used within the hospital setting or for personal use to manage excess fluid associated with congestive heart failure. It is also used as an antihypertensive. Most often... -
Low price for Doxycycline Monohydrate 100mg Dosage - Doxycycline Monohydrate – CPF
多西环素一水物 Doxycycline Monohydrate 17086-28-1 USP/EP Generic Name: doxycycline (DOX i SYE kleen) Brand Names: Acticlate, Adoxa CK, Adoxa Pak, Adoxa TT, Alodox, Avidoxy, Doryx, Mondoxyne NL, Monodox, Morgidox, Oracea, Oraxyl, Periostat Targadox, Vibramycin calcium, Vibramycin Hyclate, Vibramycin monohydrate, Vibra-Tabs Dosage Form: capsule Doxycycline is a tetracycline antibiotic that fights bacteria in the body and an antibiotic and broad-spectrum metalloproteinase (MMP) inhibi... -
Hot Selling for Ticagrelor Manufacturer - Doxycycline Hyclate – CPF
Background Doxycycline hyclate is an antibiotic [1]. Doxycycline hyclate is a derivative of tetracycline and possesses the activities of anti-inflammatory and antimicrobial. Doxycycline inhibits dengue virus replication in vitro with a temperature-dependent manner. The IC50 value is 52.3μM at 37°C and 26.7μM at 40°C. It inhibits the dengue virus via inhibiting the NS2B-NS3 serine protease of the virus. 60μM doxycycline reduces the CPE of the DNEV2-infected cells [1]. Doxycycline is found to b... -
PriceList for Canagliflozin - Atorvastatin Calcium – CPF
Background Atorvastatin Calcium is a potent inhibitor of HMG-CoA reductase with IC50 value of 150 nM[1]. HMG-CoA reductase is the key enzyme of the mevalonate pathway which produces cholesterol. HMG-CoA is the rate-limiting enzyme and is important for lowering the blood cholesterol levels. HMG-CoA reductase is located in the endoplasmic reticulum and contains eight transmembrane domains. The inhibitors of HMG-CoA reductase can induce the LDL (low density lipoprotein) receptors expression in t...