China High Quality Doxycycline Hcl Uses - Venetoclax 1257044-40-8 – CPF manufacturers and suppliers

High Quality Doxycycline Hcl Uses - Venetoclax 1257044-40-8 – CPF

Short Description:

Product Detail

Product Tags

Feedback (2)

So as to provide you with ease and enlarge our business, we even have inspectors in QC Crew and guarantee you our best company and solution for Doxycycline Monohydrate For Syphilis, Doxycycline Manufacturer, Doxycycline Monohydrate 100mg, We are sincerely looking forward to cooperate with customers all over the world. We believe we can satisfy with you. We also warmly welcome customers to visit our factory and purchase our products.

High Quality Doxycycline Hcl Uses - Venetoclax 1257044-40-8 – CPF Detail:

维奈妥拉	Venetoclax	1257044-40-8	In-House
VCL-6A		98549-88-3	In-House
VCL-7A		1235865-75-4	In-House
VCLM2		1228780-72-0	In-House
VCLM2-2HCl		1628047-87-9	In-House
VCLM3		1228779-96-1	In-House

Generic Name: venetoclax (ven ET oh klax)
Brand Name: Venclexta, Venclexta Starting Pack

Venetoclax is used to treat chronic lymphocytic leukemia or small lymphocytic leukemia in adults. Venetoclax is used alone or in combination with other cancer medicines to treat these conditions.

Venetoclax is used in combination with azacitidine, decitabine, or cytarabine to treat acute myeloid leukemia. This combination is for use in adults who are 75 years or older, or who cannot use standard chemotherapy due to other medical conditions.

Venetoclax is sometimes given after other treatments have failed.

Venetoclax may also be used for purposes not listed in this medication guide.

Description

Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy.

In Vitro

Venetoclax (ABT-199) potently kills FL5.12-BCL-2 cells (EC50=4 nM), Venetoclax (ABT-199) shows much weaker activity against FL5.12-BCL-XL cells (EC50=261 nM). ABT-199 also shows selectivity in cellular mammalian two-hybrid assays, where it disrupts BCL-2-BIM complexes (EC50=3 nM) but is much less effective against BCL-XL-BCL-XS (EC50=2.2 μM) or MCL-1-NOXA complexes.

After a single oral dose of 12.5 mg per kg body weight in xenografts derived from RS4;11 cells (ALL), Venetoclax (ABT-199) causes a maximal tumor growth inhibition (TGImax) of 47% (P<0.001) and tumor growth delay (TGD) of 26% (P<0.05)[1].

Treatment of established xenografted (a mouse xenograft model of the T-ALL cell line LOUCY) tumors with Venetoclax (ABT-199) 100 mg/kg for 4 days results in a significant reduction of leukemic burden.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Chemical structure

Venetoclax 1257044-40-8

2018 GMP-2
原料药GMP证书201811（captopril ,thalidomide etc）
GMP-of-PMDA-in-Chanyoo-平成28年08月03日　Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

OUR STRENGTH

Quality management1

Proposal 18 Quality Consistency Evaluation projects which have approved 4, and 6 projects are under approving.

Quality management2

Advanced international quality management system has laid solid foundation for sales.

Quality management3

Quality supervision runs through the whole life cycle of the product to ensure the quality and therapeutic effect.

Quality management4

Professional Regulatory Affairs team supports the quality demands during the application and registration.

VIEW MORE

VIEW MORE

International cooperation

Domestic cooperation

Product detail pictures:

Related Product Guide:

We're going to commit ourselves to giving our esteemed customers along with the most enthusiastically considerate providers for High Quality Doxycycline Hcl Uses - Venetoclax 1257044-40-8 – CPF , The product will supply to all over the world, such as: Kenya, Chile, Lahore, Our products are widely recognized and trusted by users and can meet continuously developing economic and social needs. We welcome new and old customers from all walks of life to contact us for future business relationships and achieving mutual success!

Auro Rosuvastatin Calcium

China Wholesale Rosuvastatin Calcium Tablets 10mg Factory

China Wholesale Ticagrelor 180 Mg Quotes

Doxycycline Hyclate Tablets

Timely delivery, strict implementation of the contract provisions of the goods, encountered special circumstances, but also actively cooperate, a trustworthy company!