China Hot-selling Doxycycline Hyclate Syphilis - Sacubitril Hemicalcium – CPF manufacturers and suppliers

Hot-selling Doxycycline Hyclate Syphilis - Sacubitril Hemicalcium – CPF

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It can be a great way to enhance our solutions and service. Our mission would be to build inventive products to consumers with a superior working experience for Thalidomide Leprosy, Sacubitril Manufacturer, Fenofibrate Rosuvastatin Calcium, We are trying to get for in depth cooperation with sincere shoppers, attaining a new result in of glory with customers and strategic partners.

Hot-selling Doxycycline Hyclate Syphilis - Sacubitril Hemicalcium – CPF Detail:

沙库比曲半钙盐	Sacubitril Hemicalcium	1369773-39-6	In-House
沙库比曲钠盐		149690-05-1	In-House
LCZ-4		1426129-50-1	In-House
LCZ-7		1012341-48-8	In-House
LCZ-8		1012341-50-2	In-House
LCZ-9		149690-12-0	In-House

Background

AHU-377 hemicalcium salt is a hemicalcium salt form of AHU-377. It is an inhibitor of neprilysin with IC50 value of 5 nM [1].

AHU-377 and the angiotensin II AT1 receptor antagonist valsartan compose LCZ696 in a 1:1 molar ratio. LCZ696 is an angiotensin receptor neprilysin inhibitor. It can reduce blood pressure and may be a novel drug for the treatment of heart failure. AHU-377 is a pro-drug, it can be converted by enzymatic cleavage of the ethyl ester into the active form LBQ657. It is reported that AHU-377(30 and 100 mg/kg, PO) can cause antihypertensive effect in a dose-dependent manner in DAHI-SS rats. But in the DOCA-salt hypertensive rats, it shows a weak reduction [2, 3].

References:
[1] Ksander GM, Ghai RD, deJesus R, Diefenbacher CG, Yuan A, Berry C, Sakane Y, Trapani A. Dicarboxylic acid dipeptide neutral endopeptidase inhibitors. J Med Chem. 1995 May 12; 38(10):1689-700.
[2] Voors AA, Dorhout B, van der Meer P. The potential role of valsartan + AHU377 ( LCZ696 ) in the treatment of heart failure. Expert Opin Investig Drugs. 2013 Aug;22(8):1041-7.
[3] Laxminarayan G Hegde, Cecile Yu, Cheruvu Madhavi et al. Comparative efficacy of AHU-377, a potent neprilysin inhibitor, in two rat models of volume-dependent hypertension. BMC Pharmacology 2011, 11(Suppl 1):P33.

Chemical structure

Sacubitril Hemicalcium

2018 GMP-2
原料药GMP证书201811（captopril ,thalidomide etc）
GMP-of-PMDA-in-Chanyoo-平成28年08月03日　Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

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Proposal 18 Quality Consistency Evaluation projects which have approved 4, and 6 projects are under approving.

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Our progress depends about the advanced products ,fantastic talents and continuously strengthened technology forces for Hot-selling Doxycycline Hyclate Syphilis - Sacubitril Hemicalcium – CPF , The product will supply to all over the world, such as: Wellington, Senegal, Iran, As a way to use the resource on the expanding info in international trade, we welcome prospects from everywhere on the web and offline. In spite on the high quality items we offer, effective and satisfying consultation service is supplied by our qualified after-sale service group. Item lists and detailed parameters and any other info weil be sent to you timely for the inquiries. So please make contact with us by sending us emails or call us when you've got any questions about our organization. ou could also get our address information from our site and come to our enterprise. We get a field survey of our merchandise. We are confident that we'll share mutual accomplishment and create solid co-operation relations with our companions within this market place. We're seeking forward for your inquiries.

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