Manufacturer for Doxycycline Hyclate For Cats - Sacubitril Hemicalcium – CPF
Manufacturer for Doxycycline Hyclate For Cats - Sacubitril Hemicalcium – CPF Detail:
沙库比曲半钙盐 | Sacubitril Hemicalcium | 1369773-39-6 | In-House |
沙库比曲钠盐 | 149690-05-1 | In-House | |
LCZ-4 | 1426129-50-1 | In-House | |
LCZ-7 | 1012341-48-8 | In-House | |
LCZ-8 | 1012341-50-2 | In-House | |
LCZ-9 | 149690-12-0 | In-House |
Background
AHU-377 hemicalcium salt is a hemicalcium salt form of AHU-377. It is an inhibitor of neprilysin with IC50 value of 5 nM [1].
AHU-377 and the angiotensin II AT1 receptor antagonist valsartan compose LCZ696 in a 1:1 molar ratio. LCZ696 is an angiotensin receptor neprilysin inhibitor. It can reduce blood pressure and may be a novel drug for the treatment of heart failure. AHU-377 is a pro-drug, it can be converted by enzymatic cleavage of the ethyl ester into the active form LBQ657. It is reported that AHU-377(30 and 100 mg/kg, PO) can cause antihypertensive effect in a dose-dependent manner in DAHI-SS rats. But in the DOCA-salt hypertensive rats, it shows a weak reduction [2, 3].
References:
[1] Ksander GM, Ghai RD, deJesus R, Diefenbacher CG, Yuan A, Berry C, Sakane Y, Trapani A. Dicarboxylic acid dipeptide neutral endopeptidase inhibitors. J Med Chem. 1995 May 12; 38(10):1689-700.
[2] Voors AA, Dorhout B, van der Meer P. The potential role of valsartan + AHU377 ( LCZ696 ) in the treatment of heart failure. Expert Opin Investig Drugs. 2013 Aug;22(8):1041-7.
[3] Laxminarayan G Hegde, Cecile Yu, Cheruvu Madhavi et al. Comparative efficacy of AHU-377, a potent neprilysin inhibitor, in two rat models of volume-dependent hypertension. BMC Pharmacology 2011, 11(Suppl 1):P33.
Chemical structure
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We follow our enterprise spirit of "Quality, Efficiency, Innovation and Integrity". We aim to create much more worth for our buyers with our abundant resources, highly developed machinery, experienced workers and great providers for Manufacturer for Doxycycline Hyclate For Cats - Sacubitril Hemicalcium – CPF , The product will supply to all over the world, such as: Turkmenistan, Barbados, Congo, We adopt advanced production equipment and technology, and perfect testing equipment and methods to ensure our product quality. With our high-level talents, scientific management, excellent teams, and attentive service, our products are favored by domestic and foreign customers. With your support, we will build a better tomorrow!
By Louise from Victoria - 2018.10.31 10:02
The company has rich resources, advanced machinery, experienced workers and excellent services, hope you keep improving and perfecting your products and service, wish you better!
By Arabela from Suriname - 2017.03.28 16:34