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Description

Captopril (SQ-14534) is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE).

In Vitro

Captopril (SQ-14534) has been shown to have similar morbidity and mortality benefits to those of diuretics and beta-blockers in hypertensive patients. Captopril (SQ-14534) has been shown to delay the progression of diabetic nephropathy, and enalapril and lisinopril prevent the development of nephropathy in normoalbuminuric patients with diabetes[1]. An equimolar ratio of the cis and trans states of Captopril (SQ-14534) exists in solution and that the enzyme selects only the trans state of the inhibitor that presents architectural and stereoelectronic complementarity with its substrate binding groove[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT03179163	Penn State University\|National Heart, Lung, and Blood Institute (NHLBI)	Hypertension,Essential	July 20, 2016	Phase 1\|Phase 2
NCT03660293	Tanta University	Diabetes Mellitus, Type 1	April 1, 2017	Not Applicable
NCT03147092	Centro Neurológico de Pesquisa e Reabiitação, Brazil	Hypertension\|Blood Pressure	February 1, 2018	Early Phase 1
NCT00252317	Rigshospitalet, Denmark	Aortic Stenosis	November 2005	Phase 4
NCT02217852	West China Hospital	Hypertension	August 2014	Phase 4
NCT01626469	Brigham and Women´s Hospital	Type 2 Diabetes Mellitus	May 2012	Phase 1\|Phase 2
NCT00391846	AstraZeneca	Heart Failure\|Ventricular Dysfunction, Left	October 2006	Phase 4
NCT00240656	Hebei Medical University	Hypertension, Pulmonary	October 2005	Phase 1
NCT00086723	Northwestern University\|National Cancer Institute (NCI)	Unspecified Adult Solid Tumor, Protocol Specific	July 2003	Phase 1\|Phase 2
NCT00663949	Shiraz University of Medical Sciences	Diabetic Nephropathy	February 2006	Phase 2\|Phase 3
NCT01437371	University Hospital, Clermont-Ferrand\|Servier\|LivaNova	Heart Failure	August 2011	Phase 3
NCT04288700	Ain Shams University	Infantile Hemangioma	October 1, 2019	Phase 4
NCT00223717	Vanderbilt University\|Vanderbilt University Medical Center	Hypertension	January 2001	Phase 1
NCT02770378	University of Ulm\|Reliable Cancer Therapies\|Anticancer Fund, Belgium	Glioblastoma	November 2016	Phase 1\|Phase 2
NCT01761916	Instituto Materno Infantil Prof. Fernando Figueira	Preeclampsia	January 2013	Phase 4
NCT01545479	Instituto de Cardiologia do Rio Grande do Sul	Renal Disease	January 2010	Phase 4
NCT00935805	Hospital de Clinicas de Porto Alegre\|Conselho Nacional de Desenvolvimento Científico e Tecnológico\|Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul, Brazil	Diabetes Mellitus\|Arterial Hypertension	July 2006
NCT00742040	The Hospital for Sick Children	Heart Disease	August 2008	Phase 2
NCT03613506	Wuhan University	Radiotherapy Side Effect\|Taking Captopril	October 25, 2018	Phase 2
NCT00004230	Northwestern University\|National Cancer Institute (NCI)	Cancer	October 1999	Phase 3
NCT00660309	Novartis	Type 2 Diabetes Mellitus	April 2008	Phase 4
NCT00292162	NHS Greater Glasgow and Clyde	Chronic Heart Failure\|Atrial Fibrillation	January 2007	Not Applicable
NCT01271478	Coordinación de Investigación en Salud, Mexico	Inflammation\|End-stage Renal Disease	August 2009	Phase 4
NCT04193137	Chongqing Medical University	Primary Aldosteronism	November 30, 2019
NCT00155064	National Taiwan University Hospital	Hyperaldosteronism	July 2002	Phase 4
NCT01292694	Vanderbilt University\|Vanderbilt University Medical Center	Hypertension\|Pure Autonomic Failure\|Multiple System Atrophy	March 2011	Phase 1
NCT00917345	National Taiwan University Hospital\|Novartis	Primary Aldosteronism	January 2008
NCT00077064	Radiation Therapy Oncology Group\|National Cancer Institute (NCI)\|NRG Oncology	Lung Cancer\|Pulmonary Complications\|Radiation Fibrosis	June 2003	Phase 2