Doxycycline hyclate, commonly known as doxycycline, is the most frequently used antibacterial drug in veterinary clinical diagnosis. No one can simply judge which one is better between it and fluphenazole.
In the veterinary market, one of the most common tetracycline antimicrobials is doxycycline, which is a extremely familiar drug to farmers and grassroots veterinarians. However, pharmacology and application require professional efforts, so you cannot make good use of it if you are only familiar with this drug. The antibacterial mechanism of doxycycline is that it mainly enters the bacterial cell, combines with ribosome 30S subunit target, the organelle of the bacterial cell, thus inhibiting the synthesis of bacterial proteins, and enabling itself to play effective antibacterial effect.
What diseases can be treated using doxycycline?
Doxycycline is often used for the treatment of mycoplasma in poultry and respiratory diseases in pigs, especially for mixed infections of mycoplasma and bacteria.
● Bacterial diseases
For patients with pleuropneumonia, swine pneumonia and other diseases, they can use doxycycline hydrochloride + fluphenazole + antipyretic drugs.
For actinomycetes that can cause pustules that can grow in various locations on the pig, doxycycline hydrochloride will often have better effect.
● Common body diseases
For mycoplasma, also known as wheezing, doxycycline hydrochloride + flupenthixol can be used.
Spirochetes (swine dysentery, etc.).
Doxycycline hydrochloride is more effective when administered for diseases such as blood protozoa, which we often refer to as epizootics.
Four main tetracycline antimicrobials
In the current veterinary drug market, the main tetracycline antimicrobials are doxycycline, tetracycline, oxytetracycline and chlortetracycline, which have significant differences with each other. If ordering according to sensitivity, doxycycline > tetracycline > chlortetracycline > oxytetracycline. Do you know why the sensitivity of chlortetracycline is close to oxytetracycline? In fact, before antibiotics were banned in feeds, chlortetracycline was used in animal diets extensively, at low doses, daily and for a long time, just like people eat with MSG.
The low dose, widespread, and daily feeding of chlortetracycline has improved animal performance and promoted the rapid and healthy development of the farming industry, which, however, also brings a great negative effect, that is, such dose, way and means cultivate a wider range of bacterial resistance to it. Therefore, when this kind of drug is banned using in the feed, it is a great progress in regulating the use of antibacterial drugs to transform the drug to a prescription drug that has to be given by veterinary prescription. It is estimated that, after this standardized use, after a long period of ecological restoration, its sensitivity may be restored in the future.
Why is doxycycline important?
Doxycycline hyclate powder, one of the leading tetracycline antibiotics, has been outstanding in veterinary clinic for so many years that it has become the second largest species after fluphenazole. In addition, in terms of the treatment of livestock and poultry diseases that are difficult to be cleared in a short period of time, such as non-fever, air sac salt, influenza, and mycoplasma bursa, etc., doxycycline is always playing its unique therapeutic role in the effective clinical treatment of these livestock and poultry diseases. Usually, in the treatment prescribed by veterinarians, with or without the participation of doxycycline, the result is sometimes a zero-sum game of “effective” or “ineffective”.
The demand for clinical treatment of doxycycline in the farming industry has increased dramatically over the past few years due to the ravages of bursitis, difficult-to-control respiratory diseases and especially mycoplasma bursa. Especially mycoplasma bursa, which is now not seasonal at all, occurs frequently and often throughout the year. Therefore, those who pay attention to the market of doxycycline will find that the market demand of doxycycline has lost its seasonality. Consequently, even when the country has generally entered the hot summer, the market demand for doxycycline has not cooled down because of the high temperature.
The antimicrobial spectrum of doxycycline hyclate allows it to gain excellent therapeutic effects against Gram-positive, Gram-negative, aerobic and anaerobic bacteria, as well as rickettsia, spirochetes, mycoplasma, chlamydia and some protozoa, which accounts for why doxycycline has been recognized by farmers and veterinarians for so many years. Moreover, the strength of doxycycline’s effect on Gram-positive bacteria is even better than that on Gram-negative bacteria, especially when many drugs are not helpful against Staphylococcus, the effect of doxycycline is often gratifying.
As a result, among the available tetracycline antimicrobials, doxycycline is unmatched by other antimicrobials against bacteria common to respiratory diseases such as Staphylococcus, Streptococcus pyogenes and Pneumococcus, which is one of the very important reasons why many veterinary prescriptions for the treatment of respiratory diseases can be significantly different with or without the involvement of doxycycline.
Contributions made by CPF
CPF, a leading pharmaceutical and doxycycline manufacturer of APIs and finished formulations in China finds that in fact, laboratory researchers, who may prefer to explore the truth about the disease and the genes of drug resistance, have the ultimate goal of probable completing a thesis or a research paper. This exploration and research process, however, often takes months or years, which takes simply too much time to make a disease that requires an immediate opening regimen for treatment wait. Therefore, clinically effective treatment is more often based on past data, field diagnoses and limited rapid laboratory-assisted diagnoses, and then recommendations for effective treatment are given quickly.
This kind of quick disease decision made in a short period of time will easily cause many people who do not understand the drug, especially can not accurately and more comprehensive judgment of the infection pathogenic bacteria composition spectrum to take the drug blindly and based on guessing, which is also a necessary road which a lot of people have to take in such stumbling and rolling before constantly honing into famous doctors and becoming perfect medications.
Therefore, CPF is willing to exchange with you technical knowledge related to veterinary medicine, veterinary pharmacology, veterinary prescriptions, policies, regulation, market and use, with an aim to achieve information sharing, so that the successors can climb this useful ladder upward to learn something valuable.
Post time: Aug-17-2022