China Professional Design Doxycycline Hyclate And Doxycycline Monohydrate - Agomelatine – CPF manufacturers and suppliers

Professional Design Doxycycline Hyclate And Doxycycline Monohydrate - Agomelatine – CPF

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Sticking for the perception of "Creating goods of high quality and making good friends with people today from all around the world", we constantly set the interest of shoppers to begin with for Ic Doxycycline Hyclate 100mg Tab, Hydrochlorothiazide 12.5 Tablet, Calcium Rosuvastatin, We stick to providing integration solutions for customers and hope to build long-term, stable, sincere and mutual beneficial relationships with customers. We sincerely look forward to your visit.

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Background

Agomelatine is an agonist of melatonin receptors and an antagonist of the serotonin 5-HT2C receptor with Ki values of 0.062nM and 0.268nM and IC50 value of 0.27μM, respectively for MT1, MT2 and 5-HT2C [1].

Agomelatine is a unique antidepressant and is developed for treatment of major depressive disorder (MDD). Agomelatine is selective against 5-HT2C. It shows low affinities to cloned human 5-HT2A and 5-HT1A. For melatonin receptors, agomelatine shows similar affinities to cloned human MT1 and MT2 with Ki values of 0.09nM and 0.263nM, respectively. In the in vivo studies, agomelatine causes increase of dopamine and noradrenaline levels via blocking the inhibitory input of 5-HT2C. Moreover, the administration of agomelatine counteractes the stress-induced decrease in sucrose consumption in a rat model of depression. Besides that, agomelatine exerts alleviated anxiety efficacy in a rodent model of anxiety [1].

References:
[1] Zupancic M, Guilleminault C. Agomelatine. CNS drugs, 2006, 20(12): 981-992.

Chemical structure

Agomelatine

2018 GMP-2
原料药GMP证书201811（captopril ,thalidomide etc）
GMP-of-PMDA-in-Chanyoo-平成28年08月03日　Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

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Quality management1

Proposal 18 Quality Consistency Evaluation projects which have approved 4, and 6 projects are under approving.

Quality management2

Advanced international quality management system has laid solid foundation for sales.

Quality management3

Quality supervision runs through the whole life cycle of the product to ensure the quality and therapeutic effect.

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Professional Regulatory Affairs team supports the quality demands during the application and registration.

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No matter new customer or old customer, We believe in long term and trusted relationship for Professional Design Doxycycline Hyclate And Doxycycline Monohydrate - Agomelatine – CPF , The product will supply to all over the world, such as: Qatar, Algeria, Egypt, Our company offers the full range from pre-sales to after-sales service, from product development to audit the use of maintenance, based on strong technical strength, superior product performance, reasonable prices and perfect service, we'll continue to develop, to supply the high-quality goods and services, and promote lasting cooperation with our customers, common development and create a better future.

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