professional factory for Tofacitinib Supplier - Bictegravir 1611493-60-7 – CPF

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We keep on with the theory of "quality first, provider initially, constant improvement and innovation to meet the customers" with the management and "zero defect, zero complaints" as the standard objective. To great our company, we deliver the merchandise using the fantastic excellent at the reasonable price for High Blood Pressure Hydrochlorothiazide, Canagliflozin Ppt, Doxycycline Hyclate Syphilis, We sincerely welcome overseas buyers to consult for that long-term cooperation as well as the mutual progress.
professional factory for Tofacitinib Supplier - Bictegravir 1611493-60-7 – CPF Detail:

Description

Bictegravir is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.

In Vitro

Bictegravir (BIC) inhibits the strand transfer activity with an IC50 of 7.5± 0.3 nM. Relative to its inhibition of strand transfer activity, Bictegravir is a much weaker inhibitor of 3′-processing activity of HIV-1 IN, with an IC50 of 241±51 nM. Bictegravir enhances the accumulation of 2-LTR circles ~5-fold relative to the mock-treated control and reduces the amount of authentic integration products in infected cells by 100-fold. Bictegravir potently inhibits HIV-1 replication in both MT-2 and MT-4 cells with EC50s of 1.5 and 2.4 nM, respectively. Bictegravir exhibits potent antiviral effects in both primary CD4+ T lymphocytes and monocyte-derived macrophages, with EC50s of 1.5±0.3 nM and 6.6±4.1 nM, respectively, which are comparable to values obtained in T-cell lines[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NCT Number Sponsor Condition Start Date

Phase

NCT03998176 University of Nebraska|Gilead Sciences HIV-1-infection October 9, 2019

Phase 4

NCT03789968 Thomas Jefferson University|University of Maryland, College Park|Indiana University Health|The Brooklyn Hospital Center|University of Illinois at Chicago|Nova Southeastern University|University of California, San Francisco HIV+AIDS September 1, 2019
NCT04249037 University of Colorado, Denver|Gilead Sciences HIV+AIDS March 1, 2020

Not Applicable

NCT04132674 Vancouver Infectious Diseases Centre Human Immunodeficiency Virus I Infection|Drug Use November 26, 2018

Phase 4

NCT04054089 Cristina Mussini|University of Modena and Reggio Emilia HIV Infections September 2019

Phase 4

NCT04155554 Azienda Ospedaliera Universitaria Senese|Catholic University of the Sacred Heart|Ospedale Policlinico San Martino|Azienda Ospedaliera San Paolo|Ospedale Amedeo di Savoia HIV-1-infection January 29, 2020

Phase 3

NCT02275065 Gilead Sciences HIV-1 Infection October 2014

Phase 1

NCT03711253 University of Southern California Acute HIV Infection October 14, 2019

Phase 4

NCT02400307 Gilead Sciences HIV April 17, 2015

Phase 1

NCT03499483 Fenway Community Health HIV Prevention January 24, 2019

Phase 4

NCT03502005 Midland Research Group, Inc.|Gilead Sciences Human Immunodeficiency Virus March 1, 2018

Phase 4

Chemical structure

Bictegravir-1611493-60-7

2018 GMP-2
原料药GMP证书201811(captopril ,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

OUR STRENGTH

Quality management1

Proposal 18 Quality Consistency Evaluation projects which have approved 4, and 6 projects are under approving.

Quality management2

Advanced international quality management system has laid solid foundation for sales.

Quality management3

Quality supervision runs through the whole life cycle of the product to ensure the quality and therapeutic effect. 

Quality management4

Professional Regulatory Affairs team supports the quality demands during the application and registration.


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International cooperation
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Domestic cooperation


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professional factory for Tofacitinib Supplier - Bictegravir 1611493-60-7  – CPF detail pictures


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As a way to provide you advantage and enlarge our organization, we even have inspectors in QC Crew and guarantee you our greatest assistance and product or service for professional factory for Tofacitinib Supplier - Bictegravir 1611493-60-7 – CPF , The product will supply to all over the world, such as: Philippines, Madras, Bhutan, We're introduced as a one of the growing manufacture supplier and export of our merchandise. Now we have a team of dedicated trained experienced who take care the quality and timely supply. If you are looking for Good Quality at a good price and timely delivery. Do contact us.
  • This manufacturer can keep improving and perfecting products and service, it is in line with the rules of market competition, a competitive company.
    5 Stars By Althea from Bogota - 2017.08.18 11:04
    The customer service staff's attitude is very sincere and the reply is timely and very detailed, this is very helpful for our deal,thank you.
    5 Stars By Dolores from Tajikistan - 2018.06.18 19:26
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