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Short Lead Time for Venetoclax Supplier - Bictegravir 1611493-60-7 – CPF

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continue to improve, to ensure product quality in line with market and customer standard requirements. Our company has a quality assurance system have been established for Celecoxib Manufacturer, Doxycycline Hyclate 75 Mg, Obeticholic Acid Cost, Seeing believes! We sincerely welcome the new clients abroad to build organization associations and also hope to consolidate the associations while using the long-established prospects.
Short Lead Time for Venetoclax Supplier - Bictegravir 1611493-60-7 – CPF Detail:

Description

Bictegravir is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.

In Vitro

Bictegravir (BIC) inhibits the strand transfer activity with an IC50 of 7.5± 0.3 nM. Relative to its inhibition of strand transfer activity, Bictegravir is a much weaker inhibitor of 3′-processing activity of HIV-1 IN, with an IC50 of 241±51 nM. Bictegravir enhances the accumulation of 2-LTR circles ~5-fold relative to the mock-treated control and reduces the amount of authentic integration products in infected cells by 100-fold. Bictegravir potently inhibits HIV-1 replication in both MT-2 and MT-4 cells with EC50s of 1.5 and 2.4 nM, respectively. Bictegravir exhibits potent antiviral effects in both primary CD4+ T lymphocytes and monocyte-derived macrophages, with EC50s of 1.5±0.3 nM and 6.6±4.1 nM, respectively, which are comparable to values obtained in T-cell lines[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NCT Number Sponsor Condition Start Date

Phase
NCT03998176 University of Nebraska|Gilead Sciences HIV-1-infection October 9, 2019

Phase 4
NCT03789968 Thomas Jefferson University|University of Maryland, College Park|Indiana University Health|The Brooklyn Hospital Center|University of Illinois at Chicago|Nova Southeastern University|University of California, San Francisco HIV+AIDS September 1, 2019
NCT04249037 University of Colorado, Denver|Gilead Sciences HIV+AIDS March 1, 2020

Not Applicable
NCT04132674 Vancouver Infectious Diseases Centre Human Immunodeficiency Virus I Infection|Drug Use November 26, 2018

Phase 4
NCT04054089 Cristina Mussini|University of Modena and Reggio Emilia HIV Infections September 2019

Phase 4
NCT04155554 Azienda Ospedaliera Universitaria Senese|Catholic University of the Sacred Heart|Ospedale Policlinico San Martino|Azienda Ospedaliera San Paolo|Ospedale Amedeo di Savoia HIV-1-infection January 29, 2020

Phase 3
NCT02275065 Gilead Sciences HIV-1 Infection October 2014

Phase 1
NCT03711253 University of Southern California Acute HIV Infection October 14, 2019

Phase 4
NCT02400307 Gilead Sciences HIV April 17, 2015

Phase 1
NCT03499483 Fenway Community Health HIV Prevention January 24, 2019

Phase 4
NCT03502005 Midland Research Group, Inc.|Gilead Sciences Human Immunodeficiency Virus March 1, 2018

Phase 4

Chemical structure

Bictegravir-1611493-60-7

2018 GMP-2
原料药GMP证书201811（captopril ,thalidomide etc）
GMP-of-PMDA-in-Chanyoo-平成28年08月03日　Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

OUR STRENGTH

Quality management1

Proposal 18 Quality Consistency Evaluation projects which have approved 4, and 6 projects are under approving.

Quality management2

Advanced international quality management system has laid solid foundation for sales.

Quality management3

Quality supervision runs through the whole life cycle of the product to ensure the quality and therapeutic effect. 

Quality management4

Professional Regulatory Affairs team supports the quality demands during the application and registration.


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International cooperation
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Domestic cooperation

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Our well-equipped facilities and great excellent command throughout all stages of generation enables us to guarantee total customer fulfillment for Short Lead Time for Venetoclax Supplier - Bictegravir 1611493-60-7 – CPF , The product will supply to all over the world, such as: Rotterdam, Thailand, Islamabad, Ensuring high product quality by choosing the best suppliers, now we have also implemented complete quality control processes throughout our sourcing procedures. Meanwhile, our access to a large range of factories, coupled with our excellent management, also ensures that we can quickly fill your requirements at the best prices, regardless the order size.
    • Although we are a small company, we are also respected. Reliable quality, sincere service and good credit, we are honored to be able to work with you!
    5 Stars By Dee Lopez from Sri Lanka - 2018.04.25 16:46
    As an international trading company, we have numerous partners, but about your company, I just want to say, you are really good, wide range, good quality, reasonable prices, warm and thoughtful service, advanced technology and equipment and workers have professional training, feedback and product update is timely, in short, this is a very pleasant cooperation, and we look forward to the next cooperation!
    5 Stars By Honey from Panama - 2017.06.19 13:51
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