Short Lead Time for Venetoclax Supplier - Ribociclib 1374639-75-4 – CPF

Short Description:


Product Detail

Product Tags

Related Video

Feedback (2)

So that you can finest fulfill client's demands, all of our operations are strictly performed in line with our motto "High Excellent, Competitive Price, Fast Service" for Doxycycline Hyclate 20 Mg, Doxycycline Hyclate For Bv, Metoprolol And Hydrochlorothiazide, For further queries or should you have any question regarding our products, please do not hesitate to contact us.
Short Lead Time for Venetoclax Supplier - Ribociclib 1374639-75-4 – CPF Detail:

Description

Ribociclib (LEE01) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.

 

In Vitro

Treating a panel of 17 neuroblastoma cell lines with Ribociclib (LEE011) across a four-log dose range (10 to 10,000 nM). Treatment with Ribociclib significantly inhibits substrate adherent growth relative to the control in 12 of the 17 neuroblastoma cell lines examined (mean IC50=306±68 nM, considering sensitive lines only, where sensitivity is defined as an IC50 of less than 1 μM. Ribociclib treatment of two neuroblastoma cell lines (BE2C and IMR5) with demonstrated sensitivity to CDK4/6 inhibition results in a dose-dependent accumulation of cells in the G0/G1 phase of the cell cycle. This G0/G1 arrest becomes significant at Ribociclib concentrations of 100 nM (p=0.007) and 250 nM (p=0.01), respectively.

 

CB17 immunodeficient mice bearing BE2C, NB-1643 (MYCN amplified, sensitive in vitro), or EBC1 (non-amplified, resistant in vitro) xenografts are treated once daily for 21 days with Ribociclib (LEE011; 200 mg/kg) or with a vehicle control. This dosing strategy is well tolerated, as no weight loss or other signs of toxicity are observed in any of the xenograft models. Tumor growth is significantly delayed throughout the 21 days of treatment in mice harboring the BE2C or 1643 xenografts (both, p<0.0001), although growth resumed post-treatment.

 

Storage

Powder

-20°C

3 years

4°C

2 years
In solvent

-80°C

6 months

-20°C

1 month

 

Chemical structure

Ribociclib 1374639-75-4

2018 GMP-2
原料药GMP证书201811(captopril ,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

OUR STRENGTH

Quality management1

Proposal 18 Quality Consistency Evaluation projects which have approved 4, and 6 projects are under approving.

Quality management2

Advanced international quality management system has laid solid foundation for sales.

Quality management3

Quality supervision runs through the whole life cycle of the product to ensure the quality and therapeutic effect. 

Quality management4

Professional Regulatory Affairs team supports the quality demands during the application and registration.


VIEW MORE


VIEW MORE

International cooperation
International cooperation
Domestic cooperation
Domestic cooperation


Product detail pictures:

Short Lead Time for Venetoclax Supplier - Ribociclib 1374639-75-4  – CPF detail pictures


Related Product Guide:

Our focus on should be to consolidate and enhance the quality and repair of present products, in the meantime constantly establish new products to meet unique customers' requires for Short Lead Time for Venetoclax Supplier - Ribociclib 1374639-75-4 – CPF , The product will supply to all over the world, such as: Jersey, kazan, Sri Lanka, Meanwhile, we're building up and consummating triangle market & strategic cooperation in order to achieve a multi-win trade supply chain to expand our market vertically and horizontally for a brighter prospects. development. Our philosophy is to create cost-effective products, promote perfect services, cooperate for long-term and mutual benefits, firm a comprehensive mode of excellent suppliers system and marketing agents, brand strategic cooperation sales system.
  • The company's products can meet our diverse needs, and the price is cheap, the most important is that the quality is also very nice.
    5 Stars By Donna from Jersey - 2017.06.16 18:23
    The factory has advanced equipment, experienced staffs and good management level, so product quality had assurance, this cooperation is very relaxed and happy!
    5 Stars By Pearl Permewan from Algeria - 2017.12.09 14:01
    Write your message here and send it to us