English

Special Price for Daclatasvir Plus Sofosbuvir - Venetoclax 1257044-40-8 – CPF

Special Price for Daclatasvir Plus Sofosbuvir - Venetoclax 1257044-40-8 – CPF Featured Image
  • Special Price for Daclatasvir Plus Sofosbuvir - Venetoclax 1257044-40-8 – CPF

Short Description:


Product Detail

Product Tags

Related Video

Feedback (2)

We attempt for excellence, company the customers", hopes to be the top cooperation team and dominator company for personnel, suppliers and customers, realizes price share and continual marketing for Rivaroxaban, Daclatasvir Dose, Hydrochlorothiazide Supplier, We've been confident that there'll become a promising future and we hope we can have long lasting cooperation with consumers from all over the world.
Special Price for Daclatasvir Plus Sofosbuvir - Venetoclax 1257044-40-8 – CPF Detail:

维奈妥拉 Venetoclax 1257044-40-8 In-House
    VCL-6A 98549-88-3 In-House
    VCL-7A 1235865-75-4 In-House
    VCLM2 1228780-72-0 In-House
    VCLM2-2HCl 1628047-87-9 In-House
    VCLM3 1228779-96-1 In-House

Generic Name: venetoclax (ven ET oh klax)
Brand Name: Venclexta, Venclexta Starting Pack

Venetoclax is used to treat chronic lymphocytic leukemia or small lymphocytic leukemia in adults. Venetoclax is used alone or in combination with other cancer medicines to treat these conditions.

Venetoclax is used in combination with azacitidine, decitabine, or cytarabine to treat acute myeloid leukemia. This combination is for use in adults who are 75 years or older, or who cannot use standard chemotherapy due to other medical conditions.

Venetoclax is sometimes given after other treatments have failed.

Venetoclax may also be used for purposes not listed in this medication guide.

Description

Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy.

In Vitro

Venetoclax (ABT-199) potently kills FL5.12-BCL-2 cells (EC50=4 nM), Venetoclax (ABT-199) shows much weaker activity against FL5.12-BCL-XL cells (EC50=261 nM). ABT-199 also shows selectivity in cellular mammalian two-hybrid assays, where it disrupts BCL-2-BIM complexes (EC50=3 nM) but is much less effective against BCL-XL-BCL-XS (EC50=2.2 μM) or MCL-1-NOXA complexes.

After a single oral dose of 12.5 mg per kg body weight in xenografts derived from RS4;11 cells (ALL), Venetoclax (ABT-199) causes a maximal tumor growth inhibition (TGImax) of 47% (P<0.001) and tumor growth delay (TGD) of 26% (P<0.05)[1].

Treatment of established xenografted (a mouse xenograft model of the T-ALL cell line LOUCY) tumors with Venetoclax (ABT-199) 100 mg/kg for 4 days results in a significant reduction of leukemic burden.

Storage

Powder

-20°C

 3 years

4°C

 2 years
In solvent

-80°C

 6 months

-20°C

 1 month

Chemical structure

Venetoclax 1257044-40-8

2018 GMP-2
原料药GMP证书201811（captopril ,thalidomide etc）
GMP-of-PMDA-in-Chanyoo-平成28年08月03日　Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

OUR STRENGTH

Quality management1

Proposal 18 Quality Consistency Evaluation projects which have approved 4, and 6 projects are under approving.

Quality management2

Advanced international quality management system has laid solid foundation for sales.

Quality management3

Quality supervision runs through the whole life cycle of the product to ensure the quality and therapeutic effect. 

Quality management4

Professional Regulatory Affairs team supports the quality demands during the application and registration.


VIEW MORE


VIEW MORE

International cooperation
International cooperation
Domestic cooperation
Domestic cooperation

Product detail pictures:

Special Price for Daclatasvir Plus Sofosbuvir - Venetoclax 1257044-40-8 – CPF detail pictures

Related Product Guide:
Dedicated to strict top quality command and considerate purchaser support, our experienced staff customers are always available to discuss your necessities and be certain full client gratification for Special Price for Daclatasvir Plus Sofosbuvir - Venetoclax 1257044-40-8 – CPF , The product will supply to all over the world, such as: Karachi, Jakarta, Dubai, Our solutions have national accreditation requirements for qualified, good quality products, affordable value, was welcomed by individuals all over the world. Our products will continue to improve inside the order and appear forward to cooperation with you, Definitely should any of those goods be of curiosity to you, be sure to letus know. We'll be satisfied to supply you a quotation up on receipt of the detailed needs.
    • We are a small company that has just started, but we get the company leader's attention and gave us a lot of help. Hope we can make progress together!
    5 Stars By Michelle from Montreal - 2017.03.28 16:34
    The customer service staff's answer is very meticulous, the most important is that the product quality is very good, and packaged carefully, shipped quickly!
    5 Stars By Catherine from Canada - 2017.07.07 13:00
    Write your message here and send it to us

    Products categories