English

Wholesale Discount Doxycycline Monohydrate Chlamydia - LCZ696(Sacubitril + Valsartan) – CPF

Wholesale Discount Doxycycline Monohydrate Chlamydia - LCZ696(Sacubitril + Valsartan) – CPF Featured Image
  • Wholesale Discount Doxycycline Monohydrate Chlamydia - LCZ696(Sacubitril + Valsartan) – CPF

Short Description:


Product Detail

Product Tags

Related Video

Feedback (2)

To meet the customers' over-expected pleasure , we have now our solid crew to supply our greatest all round assistance which includes marketing, sales, planning, production, top quality controlling, packing, warehousing and logistics for Favipiravir Manufacturer, Doxycycline Hyclate Before And After, Telaprevir, If needed, welcome to help make speak to with us by our web page or cellular phone consultation, we are going to be delighted to serve you.
Wholesale Discount Doxycycline Monohydrate Chlamydia - LCZ696(Sacubitril + Valsartan) – CPF Detail:

Description

LCZ696 (Sacubitril/Valsartan), comprised Valsartan (an ARB) and Sacubitril (AHU377) in 1:1 molar ratio, is a first-in-class, orally bioavailable, and dual-acting angiotensin receptor-neprilysin (ARN) inhibitor for hypertension and heart failure[1][2][3]. LCZ696 ameliorates diabetic cardiomyopathy by inhibiting inflammation, oxidative stress and apoptosis.

 

Background

LCZ696 is a first in class ARNi (angiotensin receptor neprilysin inhibitor) comprising anionic moieties of AR valsartan and the neprilysin inhibitor prodrug AHU377 (1:1 ratio) for heart failure and hypertension.

The angiotensin receptors are G-protein-coupled receptors. They mediate the cardiovascular and other effects of angiotensin II which is a bioactive peptide of the renin–angiotensin system. Neprilysin is a neutral endopeptidase that degrades endogenous vasoactive peptides such as natriuretic peptides. Inhibition of neprilysin increases the natriuretic peptides concentration that contributed to cardiac, vascular and renal protection. [1]

In Sprague-Dawley rats, oral administration of LCZ696 led to a dose-dependent rise in immunoreactivity of atrial natriuretic peptide resulting from neprilysin inhibition. In hypertensive double transgenic rats, LCZ696 caused a dose-dependent and sustained reduction in mean arterial pressure. A healthy participants, a randomized, double-blind, placebo-controlled study confirmed that LCZ696 provided concurrent neprilysin inhibition and AT1 receptor blockade. LCZ696 was safe and well tolerated in human. [2] [3]

References:
McMurray JJ, Packer M, Desai AS et al.  Angiotensin-neprilysin inhibition versus enalapril in heart failure. N Engl J Med. 2014 Sep 11;371(11):993-1004.
Gu J, Noe A, Chandra P, Al-Fayoumi S et al.  Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi). J Clin Pharmacol. 2010 Apr;50(4):401-14.
Langenickel TH, Dole WP.  Angiotensin receptor-neprilysin inhibition with LCZ696: a novel approach for the treatment of heart failure, Drug Discov Today: Ther Strategies (2014),

 

Storage

Powder

-20°C

 3 years
 

4°C

 2 years
In solvent

-80°C

 6 months
 

-20°C

 1 month

Chemical structure

LCZ696(Sacubitril + Valsartan)

2018 GMP-2
原料药GMP证书201811（captopril ,thalidomide etc）
GMP-of-PMDA-in-Chanyoo-平成28年08月03日　Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

OUR STRENGTH

Quality management1

Proposal 18 Quality Consistency Evaluation projects which have approved 4, and 6 projects are under approving.

Quality management2

Advanced international quality management system has laid solid foundation for sales.

Quality management3

Quality supervision runs through the whole life cycle of the product to ensure the quality and therapeutic effect. 

Quality management4

Professional Regulatory Affairs team supports the quality demands during the application and registration.


VIEW MORE


VIEW MORE

International cooperation
International cooperation
Domestic cooperation
Domestic cooperation

Product detail pictures:

Wholesale Discount Doxycycline Monohydrate Chlamydia - LCZ696(Sacubitril + Valsartan) – CPF detail pictures

Related Product Guide:
The key to our success is "Good Product Quality, Reasonable Value and Efficient Service" for Wholesale Discount Doxycycline Monohydrate Chlamydia - LCZ696(Sacubitril + Valsartan) – CPF , The product will supply to all over the world, such as: Pakistan, Congo, Nigeria, We always insist on the management tenet of "Quality is first, Technology is basis, Honesty and Innovation".We are able to develop new products continuously to a higher level to satisfy different needs of customers.
    • Although we are a small company, we are also respected. Reliable quality, sincere service and good credit, we are honored to be able to work with you!
    5 Stars By Julie from Bangladesh - 2017.11.11 11:41
    We feel easy to cooperate with this company, the supplier is very responsible, thanks.There will be more in-depth cooperation.
    5 Stars By Emily from luzern - 2018.10.31 10:02
    Write your message here and send it to us

    Products categories